A New Case of Syringocystadenocarcinoma Papilliferum: a Rare Pathology for a Wide-ranging Comprehension

Overview

Journal Case Rep Med

Publisher Wiley

Specialty General Medicine

Date 2014 Jun 25

PMID 24959179

Citations 11

Authors

Beatrice Paradiso

Enzo Bianchini

Pierangelo Cifelli

Luigi Cavazzini

Giovanni Lanza

Affiliations

Soon will be listed here.

Abstract

We report a new case of p63/cytokeratin 7 (CK7) positive syringocystadenocarcinoma papilliferum (SCACP), on the shoulder of an 88-year-old man, with superficial dermal infiltration and squamoid differentiation. We describe the 24th case of SCACP, the malignant counterpart of syringocystadenoma papilliferum (SCAP). At the present, we do not know whether SCACP arises from eccrine or apocrine glands because of the contrasting opinions in the literature. Only few histochemical and ultrastructural studies have previously advised that SCACP could arise from pluripotent stem cells. Through our case, we wish to suggest the stem cell-like properties of the syringocystadenocarcinoma papilliferum. This rare neoplasm shows two different patterns of stem cell marker expression in the glandular and squamous components, respectively. For the double phenotype of SCACP, we propose it like an intriguing model to study histogenesis and stem cell properties for more wide-ranging epithelial tumors.

Citing Articles

Syringocystadenocarcinoma of the perianal region: a case report.

Boujguenna I, Boukis F, Sefiani S, Ramraoui M J Med Case Rep. 2024; 18(1):579.

PMID: 39614403 PMC: 11606064. DOI: 10.1186/s13256-024-04927-z.

Syringocystadenoma Papilliferum: A Challenging Clinical Diagnosis in a Patient With a Persistent Scalp Lesion After Trauma.

Aljehani F, Almoqati M, Alyamani N, Ahmed W, Roblah T, Allehaibi L Cureus. 2024; 16(9):e68960.

PMID: 39385868 PMC: 11461806. DOI: 10.7759/cureus.68960.

Syringocystadenocarcinoma papilliferum: a systematic review of clinical characteristics, reappraisal of associations, diagnostic pitfalls and management challenges.

Wan L, Park A, Khachemoune A Arch Dermatol Res. 2024; 316(7):421.

PMID: 38904691 DOI: 10.1007/s00403-024-03176-w.

Syringocystadenocarcinoma Papilliferum of External Auditory Canal: First Case Report in English Literature.

Verma R, Verma R Indian J Otolaryngol Head Neck Surg. 2023; 74(Suppl 3):3700-3705.

PMID: 36742756 PMC: 9895180. DOI: 10.1007/s12070-021-02434-x.

Syringocystadenoma papilliferum in a 20-year-old adult: a case report and literature review.

Candrawinata V, Koerniawan H, Prasetiyo P, Baskoro B J Surg Case Rep. 2022; 2022(10):rjac470.

PMID: 36419953 PMC: 9596167. DOI: 10.1093/jscr/rjac470.

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