Epithelial-to-mesenchymal Transition and Cancer Stem(-like) Cells in Head and Neck Squamous Cell Carcinoma

Overview

Journal Cancer Lett

Specialty Oncology

Date 2012 Jul 10

PMID 22771535

Citations 48

Authors

Chao Chen

Miriam Zimmermann

Inge Tinhofer

Andreas M Kaufmann

Andreas E Albers

Affiliations

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Abstract

Head and neck squamous cell carcinoma (HNSCC) is the 6th commonest cancer worldwide. Relapse, thought to involve cancer stem(-like) cells (CSCs), and the development of metastases are common and survival rates remain low. Epithelial-to-mesenchymal transition (EMT) is a key event in metastasis and increasing evidence suggests a link between EMT and CSCs. MicroRNAs regulate multiple cellular processes including EMT and have been implicated in a CSC phenotype. This review aims to highlight key events that are involved in EMT, discusses their relevance in HNSCC progression and metastasis and explores the possibility of targeting EMT as a novel therapy in HNSCC.

Citing Articles

Transcription Factors and Markers Related to Epithelial-Mesenchymal Transition and Their Role in Resistance to Therapies in Head and Neck Cancers.

Pawlicka M, Gumbarewicz E, Blaszczak E, Stepulak A Cancers (Basel). 2024; 16(7).

PMID: 38611032 PMC: 11010970. DOI: 10.3390/cancers16071354.

A radiobiological perspective on radioresistance or/and radiosensitivity of head and neck squamous cell carcinoma.

Li C, Tan X, Wei W, Li M, Zhang W, Gong Z Rep Pract Oncol Radiother. 2024; 28(6):809-822.

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Radioresistance or/and radiosensitivity of head and neck squamous cell carcinoma: biological angle.

Li C, Gong Z, Zhang W, Zhang Y, Zhao H Oral Maxillofac Surg. 2023; 28(2):547-555.

PMID: 37935817 DOI: 10.1007/s10006-023-01189-9.

The Role of Exosomes in Epithelial-to-Mesenchymal Transition and Cell Functional Properties in Head and Neck Cancer.

Mastronikolis N, Kyrodimos E, Spyropoulou D, Delides A, Giotakis E, Piperigkou Z Cancers (Basel). 2023; 15(7).

PMID: 37046817 PMC: 10093122. DOI: 10.3390/cancers15072156.

The Significance of Cancer Stem Cells and Epithelial-Mesenchymal Transition in Metastasis and Anti-Cancer Therapy.

Liang L, Kaufmann A Int J Mol Sci. 2023; 24(3).

PMID: 36768876 PMC: 9917228. DOI: 10.3390/ijms24032555.