Sex Differences in the Acute in Vivo Effects of Different Human SP-A Variants on the Mouse Alveolar Macrophage Proteome

Overview

Journal J Proteomics

Publisher Elsevier

Specialty Biochemistry

Date 2014 Jun 24

PMID 24954098

Citations 24

Authors

David S Phelps

Todd M Umstead

Joanna Floros

Affiliations

Soon will be listed here.

Abstract

Biological Significance: This study shows that changes occur in the alveolar macrophage proteome in response to a single in vivo treatment with exogenous SP-A1 and/or SP-A2. We demonstrate that SP-A1 and SP-A2 have different effects on the AM proteome and that sex differences exist in the response to each SP-A1 and SP-A2 gene product. This study illustrates the potential of exogenous SP-A1 and SP-A2 treatment for the manipulation of macrophage function and indicates that the specific SP-A variant used for treatment may vary with sex and with the cellular functions being modified. The observed changes may contribute to sex differences in the incidence of some lung diseases.

Citing Articles

The Lung Alveolar Cell (LAC) miRNome and Gene Expression Profile of the SP-A-KO Mice After Infection With and Without Rescue With Human Surfactant Protein-A2 (1A).

Thorenoor N, Floros J Front Immunol. 2022; 13:854434.

PMID: 35844510 PMC: 9283764. DOI: 10.3389/fimmu.2022.854434.

Comparison of the Toponomes of Alveolar Macrophages From Wild Type and Surfactant Protein A Knockout Mice and Their Response to Infection.

Phelps D, Chinchilli V, Zhang X, Shearer D, Weisz J, Floros J Front Immunol. 2022; 13:853611.

PMID: 35572576 PMC: 9094576. DOI: 10.3389/fimmu.2022.853611.

Surfactant Protein-A Function: Knowledge Gained From SP-A Knockout Mice.

Depicolzuane L, Phelps D, Floros J Front Pediatr. 2022; 9:799693.

PMID: 35071140 PMC: 8777267. DOI: 10.3389/fped.2021.799693.

Human Surfactant Protein SP-A1 and SP-A2 Variants Differentially Affect the Alveolar Microenvironment, Surfactant Structure, Regulation and Function of the Alveolar Macrophage, and Animal and Human Survival Under Various Conditions.

Floros J, Thorenoor N, Tsotakos N, Phelps D Front Immunol. 2021; 12:681639.

PMID: 34484180 PMC: 8415824. DOI: 10.3389/fimmu.2021.681639.

Imaging NAD(H) Redox Alterations in Cryopreserved Alveolar Macrophages from Ozone-Exposed Mice and the Impact of Nutrient Starvation during Long Lag Times.

Xu H, Floros J, Li L, Amatya S Antioxidants (Basel). 2021; 10(5).

PMID: 34065846 PMC: 8151465. DOI: 10.3390/antiox10050767.

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