David S Phelps
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Explore the profile of David S Phelps including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Phelps D, Chinchilli V, Zhang X, Shearer D, Weisz J, Floros J
Front Immunol
. 2022 May;
13:853611.
PMID: 35572576
Background: Surfactant protein-A (SP-A) plays a critical role in lung innate immunity by regulating alveolar macrophages (AM), expression of inflammatory mediators, and other host defense proteins. The toponome imaging system...
2.
Phelps D, Chinchilli V, Yang L, Shearer D, Weisz J, Zhang X, et al.
Sci Rep
. 2022 Mar;
12(1):5039.
PMID: 35322074
Using the Toponome Imaging System (TIS), a serial immunostainer, we studied the patterns of expression of multiple markers in alveolar macrophages (AM) from female mice lacking surfactant protein A (SP-A...
3.
MacNeill C, Umstead T, Shearer D, Weisz J, Phelps D, Floros J
J Low Genit Tract Dis
. 2022 Mar;
26(2):169-175.
PMID: 35249975
Objective: Many women are affected by vulvodynia, but medical therapies to date have proven ineffective. We performed a pilot study using gel-based proteomics to develop a map of proteins present...
4.
Depicolzuane L, Phelps D, Floros J
Front Pediatr
. 2022 Jan;
9:799693.
PMID: 35071140
Pulmonary surfactant proteins have many roles in surfactant- related functions and innate immunity. One of these proteins is the surfactant protein A (SP-A) that plays a role in both surfactant-related...
5.
Floros J, Thorenoor N, Tsotakos N, Phelps D
Front Immunol
. 2021 Sep;
12:681639.
PMID: 34484180
The human innate host defense molecules, SP-A1 and SP-A2 variants, differentially affect survival after infection in mice and in lung transplant patients. SP-A interacts with the sentinel innate immune cell...
6.
Abbasi A, Phelps D, Ravi R, Floros J
Antioxidants (Basel)
. 2021 Apr;
10(5).
PMID: 33922049
In this opinion article, we discuss a serendipitous observation we made in a study investigating survival in aged mice after bacterial infection. This observation involved a non-invasive ventilation approach that...
7.
Thorenoor N, Phelps D, Floros J
Antioxidants (Basel)
. 2020 Dec;
9(12).
PMID: 33260937
Background: Human SP-A1 and SP-A2, encoded by and , and their genetic variants differentially impact alveolar macrophage (AM) functions and regulation, including the miRNome. We investigated whether miRNome differences previously...
8.
Phelps D, Chinchilli V, Weisz J, Yang L, Shearer D, Zhang X, et al.
JCI Insight
. 2020 Nov;
5(24).
PMID: 33141765
Alveolar macrophages (AMs) are differentially regulated by human surfactant protein-A1 (SP-A1) or SP-A2. However, AMs are very heterogeneous and differences are difficult to characterize in intact cells. Using the Toponome...
9.
Gandhi C, Mikerov A, Durrani F, Umstead T, Hu S, Wang G, et al.
Microorganisms
. 2020 Sep;
8(9).
PMID: 32899781
Surfactant protein A (SP-A) plays an important role in innate immunity. The sex-dependent survival of infected SP-A knockout (KO) mice has been observed. Our goal was to study the impact...
10.
Tekos F, Skaperda Z, Goutzourelas N, Phelps D, Floros J, Kouretas D
Antioxidants (Basel)
. 2020 Aug;
9(9).
PMID: 32854247
The pandemic of COVID-19 is of great concern to the scientific community. This mainly affects the elderly and people with underlying diseases. People with obesity are more likely to experience...