CD4 T-cell Memory Generation and Maintenance

Overview

Journal Crit Rev Immunol

Publisher Begell House

Specialty Allergy & Immunology

Date 2014 Jun 19

PMID 24940912

Citations 68

Authors

David J Gasper

Melba Marie Tejera

M Suresh

Affiliations

Soon will be listed here.

Abstract

Immunologic memory is the adaptive immune system's powerful ability to remember a previous antigen encounter and react with accelerated vigor upon antigen re-exposure. It provides durable protection against reinfection with pathogens and is the foundation for vaccine-induced immunity. Unlike the relatively restricted immunologic purview of memory B cells and CD8 T cells, the field of CD4 T-cell memory must account for multiple distinct lineages with diverse effector functions, the issue of lineage commitment and plasticity, and the variable distribution of memory cells within each lineage. Here, we discuss the evidence for lineage-specific CD4 T-cell memory and summarize the known factors contributing to memory-cell generation, plasticity, and long-term maintenance.

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