Basal Luteinizing Hormone and Follicular Stimulating Hormone: is It Sufficient for the Diagnosis of Precocious Puberty in Girls?

Overview

Journal Ann Pediatr Endocrinol Metab

Specialty Pediatrics

Date 2014 Jun 7

PMID 24904877

Citations 21

Authors

Dong Seong Lee

Na Yung Ryoo

Sun Hee Lee

Sollip Kim

Jae Hyun Kim

Affiliations

Soon will be listed here.

Abstract

Purpose: A gonadotropin-releasing hormone stimulation test (GnRHST) is the gold standard in diagnosing central precocious puberty (CPP). The aim of this study was to investigate the diagnostic accuracy of basal gonadotropin levels for girls with suspected precocious puberty and to evaluate the factors affecting positive results of the GnRHST.

Methods: Korean girls with early pubertal development who visited the clinic during 2010-2012 were included. Auxological and biochemical tests were evaluated and a standard GnRHST was performed. A peak luteinizing hormone (LH) level of ≥5 IU/L was considered a positive response during the GnRHST.

Results: A total of 336 girls were included. The positive responses were observed in 241 girls (71.7%), and negative responses were found in 95 girls (28.3%). In the logistic regression analysis, the coefficient of the basal LH and basal LH/follicular stimulating hormone (FSH) ratio was 4.23 (P<0.001) and 21.28 (P<0.001), respectively. Receiver operating characteristic analysis showed that the basal LH/FSH ratio is a better predictor of the pubertal result after the GnRHST than the basal LH (area under the curve was 0.745 and 0.740, respectively; P=0.027). Among 189 girls with a basal LH of <0.1 IU/L, 105 (55.6%) had positive responses.

Conclusion: An elevated level of the basal LH and basal LH/FSH ratio was a significant predicting factor of positive responses during the GnRHST. However a GnRHST was still necessary for diagnostic confirmation of CPP because more than half of the girls with a basal LH level below the detection limit revealed to have CPP.

Citing Articles

Does Basal Morning Luteinizing Hormone (bLH) Predict Central Precocious Puberty (CPP) in Girls?.

Baronio F, Assirelli V, Deiana G, AlQaisi R, Ortolano R, Di Natale V Medicina (Kaunas). 2024; 60(3).

PMID: 38541222 PMC: 10972438. DOI: 10.3390/medicina60030497.

Screening for central precocious puberty by single basal Luteinizing Hormone levels.

Li Pomi A, Scalini P, De Masi S, Corica D, Pepe G, Wasniewska M Endocrine. 2024; 85(2):955-963.

PMID: 38507183 PMC: 11291536. DOI: 10.1007/s12020-024-03781-9.

Urine Sampling Protocol Recommendations for Reliable Determination of Total Urinary Luteinizing Hormone Immunoreactivity in the Pediatric Population.

Demir A, Aydin A, Buyukgebiz A Children (Basel). 2023; 10(12).

PMID: 38136121 PMC: 10741787. DOI: 10.3390/children10121919.

Precocious Puberty: Types, Pathogenesis and Updated Management.

Alghamdi A Cureus. 2023; 15(10):e47485.

PMID: 38021712 PMC: 10663169. DOI: 10.7759/cureus.47485.

Metabolic characteristics and pathogenesis of precocious puberty in girls: the role of perfluorinated compounds.

Wu J, Chen J, Huang R, Zhu H, Che L, Lin Y BMC Med. 2023; 21(1):323.

PMID: 37626398 PMC: 10463894. DOI: 10.1186/s12916-023-03032-0.

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