Intratumoral Heterogeneous F-18 Fluorodeoxyglucose Uptake Corresponds with Glucose Transporter-1 and Ki-67 Expression in a Case of Krukenberg Tumor: Localization of Intratumoral Hypermetabolic Focus by Fused PET/MR Image

Overview

Journal Nucl Med Mol Imaging

Publisher Springer

Date 2014 Jun 6

PMID 24899993

Authors

Hyung-Jun Im

Yong-Il Kim

Woo Ho Kim

Seung Hyup Kim

Keon Wook Kang

Affiliations

Soon will be listed here.

Abstract

The expression of glucose transporters (Glut-1, Glut-3), hexokinase-II, and Ki-67 has been proposed to explain intratumoral heterogeneous F-18 fluorodeoxyglucose (FDG) uptake. We report a case of Krukenberg tumor with intratumoral heterogeneous FDG uptake which corresponded well with the expression levels of Glut-1 and ki-67. Fused positron emission tomography (PET)/magnetic resonance (MR) imaging was helpful for localizing the metabolically active area in the tumor specimen. This report elucidates the relationship between the intratumoral heterogeneous FDG uptake and biologic heterogeneity, and shows the usefulness of PET/MR in research on intratumoral heterogeneity.

References

van Baardwijk A, Dooms C, van Suylen R, Verbeken E, Hochstenbag M, Dehing-Oberije C . The maximum uptake of (18)F-deoxyglucose on positron emission tomography scan correlates with survival, hypoxia inducible factor-1alpha and GLUT-1 in non-small cell lung cancer. Eur J Cancer. 2007; 43(9):1392-8. DOI: 10.1016/j.ejca.2007.03.027. View

Basu S, Nair N, Banavali S . Uptake characteristics of fluorodeoxyglucose (FDG) in deep fibromatosis and abdominal desmoids: potential clinical role of FDG-PET in the management. Br J Radiol. 2007; 80(957):750-6. DOI: 10.1259/bjr/53719785. View

Pugachev A, Ruan S, Carlin S, Larson S, Campa J, Ling C . Dependence of FDG uptake on tumor microenvironment. Int J Radiat Oncol Biol Phys. 2005; 62(2):545-53. DOI: 10.1016/j.ijrobp.2005.02.009. View

Ames J, Blodgett T, Meltzer C . 18F-FDG uptake in an ovary containing a hemorrhagic corpus luteal cyst: false-positive PET/CT in a patient with cervical carcinoma. AJR Am J Roentgenol. 2005; 185(4):1057-9. DOI: 10.2214/AJR.04.1282. View

Hockel M, Schlenger K, Aral B, Mitze M, Schaffer U, Vaupel P . Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res. 1996; 56(19):4509-15. View

Thorwarth D, Eschmann S, Paulsen F, Alber M . A model of reoxygenation dynamics of head-and-neck tumors based on serial 18F-fluoromisonidazole positron emission tomography investigations. Int J Radiat Oncol Biol Phys. 2007; 68(2):515-21. DOI: 10.1016/j.ijrobp.2006.12.037. View

Bachtiary B, Boutros P, Pintilie M, Shi W, Bastianutto C, Li J . Gene expression profiling in cervical cancer: an exploration of intratumor heterogeneity. Clin Cancer Res. 2006; 12(19):5632-40. DOI: 10.1158/1078-0432.CCR-06-0357. View

van Baardwijk A, Bosmans G, van Suylen R, van Kroonenburgh M, Hochstenbag M, Geskes G . Correlation of intra-tumour heterogeneity on 18F-FDG PET with pathologic features in non-small cell lung cancer: a feasibility study. Radiother Oncol. 2008; 87(1):55-8. DOI: 10.1016/j.radonc.2008.02.002. View

Britten R, Evans A, Franko A, Pearcey R . Intratumoral heterogeneity as a confounding factor in clonogenic assays for tumour radioresponsiveness. Radiother Oncol. 1996; 39(2):145-53. DOI: 10.1016/0167-8140(96)01719-7. View

10.

Hommura F, Dosaka-Akita H, Mishina T, Nishi M, Kojima T, Hiroumi H . Prognostic significance of p27KIP1 protein and ki-67 growth fraction in non-small cell lung cancers. Clin Cancer Res. 2000; 6(10):4073-81. View

11.

Zhao S, Kuge Y, Mochizuki T, Takahashi T, Nakada K, Sato M . Biologic correlates of intratumoral heterogeneity in 18F-FDG distribution with regional expression of glucose transporters and hexokinase-II in experimental tumor. J Nucl Med. 2005; 46(4):675-82. View

12.

Kidd E, Grigsby P . Intratumoral metabolic heterogeneity of cervical cancer. Clin Cancer Res. 2008; 14(16):5236-41. DOI: 10.1158/1078-0432.CCR-07-5252. View

13.

THOMLINSON R, GRAY L . The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer. 1955; 9(4):539-49. PMC: 2073776. DOI: 10.1038/bjc.1955.55. View

14.

Chung N, Ting L, Hsu W, Lui L, Wang P . Impact of magnetic resonance imaging versus CT on nasopharyngeal carcinoma: primary tumor target delineation for radiotherapy. Head Neck. 2004; 26(3):241-6. DOI: 10.1002/hed.10378. View

15.

Guo J, Higashi K, Ueda Y, Oguchi M, Takegami T, Toga H . Microvessel density: correlation with 18F-FDG uptake and prognostic impact in lung adenocarcinomas. J Nucl Med. 2006; 47(3):419-25. View

16.

Kubota R, Yamada S, Kubota K, Ishiwata K, Tamahashi N, Ido T . Intratumoral distribution of fluorine-18-fluorodeoxyglucose in vivo: high accumulation in macrophages and granulation tissues studied by microautoradiography. J Nucl Med. 1992; 33(11):1972-80. View

17.

Delorme S, Knopp M . Non-invasive vascular imaging: assessing tumour vascularity. Eur Radiol. 1998; 8(4):517-27. DOI: 10.1007/s003300050428. View

18.

Lee A . Nasopharyngeal cancer: advances in radiotherapy. Int J Radiat Oncol Biol Phys. 2007; 69(2 Suppl):S115-7. DOI: 10.1016/j.ijrobp.2007.05.042. View

19.

Kubota R, Kubota K, Yamada S, Tada M, Ido T, Tamahashi N . Active and passive mechanisms of [fluorine-18] fluorodeoxyglucose uptake by proliferating and prenecrotic cancer cells in vivo: a microautoradiographic study. J Nucl Med. 1994; 35(6):1067-75. View

20.

von Schulthess G, Schlemmer H . A look ahead: PET/MR versus PET/CT. Eur J Nucl Med Mol Imaging. 2008; 36 Suppl 1:S3-9. DOI: 10.1007/s00259-008-0940-9. View