Playing and Listening to Tailor-made Notched Music: Cortical Plasticity Induced by Unimodal and Multimodal Training in Tinnitus Patients

Overview

Journal Neural Plast

Specialty Neurology

Date 2014 Jun 5

PMID 24895541

Citations 11

Authors

Janna Pape

Evangelos Paraskevopoulos

Maximilian Bruchmann

Andreas Wollbrink

Claudia Rudack

Christo Pantev

Affiliations

Soon will be listed here.

Abstract

BACKGROUND. The generation and maintenance of tinnitus are assumed to be based on maladaptive functional cortical reorganization. Listening to modified music, which contains no energy in the range of the individual tinnitus frequency, can inhibit the corresponding neuronal activity in the auditory cortex. Music making has been shown to be a powerful stimulator for brain plasticity, inducing changes in multiple sensory systems. Using magnetoencephalographic (MEG) and behavioral measurements we evaluated the cortical plasticity effects of two months of (a) active listening to (unisensory) versus (b) learning to play (multisensory) tailor-made notched music in nonmusician tinnitus patients. Taking into account the fact that uni- and multisensory trainings induce different patterns of cortical plasticity we hypothesized that these two protocols will have different affects. RESULTS. Only the active listening (unisensory) group showed significant reduction of tinnitus related activity of the middle temporal cortex and an increase in the activity of a tinnitus-coping related posterior parietal area. CONCLUSIONS. These findings indicate that active listening to tailor-made notched music induces greater neuroplastic changes in the maladaptively reorganized cortical network of tinnitus patients while additional integration of other sensory modalities during training reduces these neuroplastic effects.

Citing Articles

EEG spectral and microstate analysis originating residual inhibition of tinnitus induced by tailor-made notched music training.

Zhu M, Gong Q Front Neurosci. 2023; 17:1254423.

PMID: 38148944 PMC: 10750374. DOI: 10.3389/fnins.2023.1254423.

Eavesdropping on Tinnitus Using MEG: Lessons Learned and Future Perspectives.

Reisinger L, Demarchi G, Weisz N J Assoc Res Otolaryngol. 2023; 24(6):531-547.

PMID: 38015287 PMC: 10752863. DOI: 10.1007/s10162-023-00916-z.

A Randomized, Controlled Trial of Notched Music Therapy for Tinnitus Patients.

Therdphaothai J, Atipas S, Suvansit K, Prakairungthong S, Thongyai K, Limviriyakul S J Int Adv Otol. 2021; 17(3):221-227.

PMID: 34100746 PMC: 9450089. DOI: 10.5152/iao.2021.9385.

Cortical Activation Patterns of Different Masking Noises and Correlation With Their Masking Efficacy, Determined by Functional Near-Infrared Spectroscopy.

Sun Q, Wang X, Huang B, Sun J, Li J, Zhuang H Front Hum Neurosci. 2020; 14:149.

PMID: 32410973 PMC: 7198837. DOI: 10.3389/fnhum.2020.00149.

Individual Reliability of the Standard Clinical Method vs Patient-Centered Tinnitus Likeness Rating for Assessment of Tinnitus Pitch and Loudness Matching.

Hebert S JAMA Otolaryngol Head Neck Surg. 2018; 144(12):1136-1144.

PMID: 30267085 PMC: 6583084. DOI: 10.1001/jamaoto.2018.2416.

References

Kang E, Lee D, Lee J, Kang H, Hwang C, Oh S . Developmental hemispheric asymmetry of interregional metabolic correlation of the auditory cortex in deaf subjects. Neuroimage. 2003; 19(3):777-83. DOI: 10.1016/s1053-8119(03)00118-6. View

Kaltenbach J . Tinnitus: Models and mechanisms. Hear Res. 2010; 276(1-2):52-60. PMC: 3109239. DOI: 10.1016/j.heares.2010.12.003. View

Pantev C, Okamoto H, Teismann H . Music-induced cortical plasticity and lateral inhibition in the human auditory cortex as foundations for tonal tinnitus treatment. Front Syst Neurosci. 2012; 6:50. PMC: 3384223. DOI: 10.3389/fnsys.2012.00050. View

Zatorre R, Chen J, Penhune V . When the brain plays music: auditory-motor interactions in music perception and production. Nat Rev Neurosci. 2007; 8(7):547-58. DOI: 10.1038/nrn2152. View

Johnsrude I, Penhune V, Zatorre R . Functional specificity in the right human auditory cortex for perceiving pitch direction. Brain. 1999; 123 ( Pt 1):155-63. DOI: 10.1093/brain/123.1.155. View

Pardo J, Fox P, Raichle M . Localization of a human system for sustained attention by positron emission tomography. Nature. 1991; 349(6304):61-4. DOI: 10.1038/349061a0. View

Feldman D . Synaptic mechanisms for plasticity in neocortex. Annu Rev Neurosci. 2009; 32:33-55. PMC: 3071739. DOI: 10.1146/annurev.neuro.051508.135516. View

Schlee W, Weisz N, Bertrand O, Hartmann T, Elbert T . Using auditory steady state responses to outline the functional connectivity in the tinnitus brain. PLoS One. 2008; 3(11):e3720. PMC: 2579484. DOI: 10.1371/journal.pone.0003720. View

Ridder D, Vanneste S, Weisz N, Londero A, Schlee W, Elgoyhen A . An integrative model of auditory phantom perception: tinnitus as a unified percept of interacting separable subnetworks. Neurosci Biobehav Rev. 2013; 44:16-32. DOI: 10.1016/j.neubiorev.2013.03.021. View

10.

Petkov C, Kang X, Alho K, Bertrand O, Yund E, Woods D . Attentional modulation of human auditory cortex. Nat Neurosci. 2004; 7(6):658-63. DOI: 10.1038/nn1256. View

11.

Mirz F, Gjedde A, Ishizu K, Pedersen C . Cortical networks subserving the perception of tinnitus--a PET study. Acta Otolaryngol Suppl. 2000; 543:241-3. DOI: 10.1080/000164800454503. View

12.

Weisz N, Moratti S, Meinzer M, Dohrmann K, Elbert T . Tinnitus perception and distress is related to abnormal spontaneous brain activity as measured by magnetoencephalography. PLoS Med. 2005; 2(6):e153. PMC: 1160568. DOI: 10.1371/journal.pmed.0020153. View

13.

Vanneste S, Plazier M, van der Loo E, Van de Heyning P, Ridder D . The difference between uni- and bilateral auditory phantom percept. Clin Neurophysiol. 2010; 122(3):578-587. DOI: 10.1016/j.clinph.2010.07.022. View

14.

Ridder D, Elgoyhen A, Romo R, Langguth B . Phantom percepts: tinnitus and pain as persisting aversive memory networks. Proc Natl Acad Sci U S A. 2011; 108(20):8075-80. PMC: 3100980. DOI: 10.1073/pnas.1018466108. View

15.

Turrigiano G . The self-tuning neuron: synaptic scaling of excitatory synapses. Cell. 2008; 135(3):422-35. PMC: 2834419. DOI: 10.1016/j.cell.2008.10.008. View

16.

Herholz S, Zatorre R . Musical training as a framework for brain plasticity: behavior, function, and structure. Neuron. 2012; 76(3):486-502. DOI: 10.1016/j.neuron.2012.10.011. View

17.

Middleton J, Kiritani T, Pedersen C, Turner J, Shepherd G, Tzounopoulos T . Mice with behavioral evidence of tinnitus exhibit dorsal cochlear nucleus hyperactivity because of decreased GABAergic inhibition. Proc Natl Acad Sci U S A. 2011; 108(18):7601-6. PMC: 3088638. DOI: 10.1073/pnas.1100223108. View

18.

Zeman F, Koller M, Schecklmann M, Langguth B, Landgrebe M . Tinnitus assessment by means of standardized self-report questionnaires: psychometric properties of the Tinnitus Questionnaire (TQ), the Tinnitus Handicap Inventory (THI), and their short versions in an international and multi-lingual sample. Health Qual Life Outcomes. 2012; 10:128. PMC: 3541124. DOI: 10.1186/1477-7525-10-128. View

19.

Pantev C, Herholz S . Plasticity of the human auditory cortex related to musical training. Neurosci Biobehav Rev. 2011; 35(10):2140-54. DOI: 10.1016/j.neubiorev.2011.06.010. View

20.

Eggermont J . Cortical tonotopic map reorganization and its implications for treatment of tinnitus. Acta Otolaryngol Suppl. 2006; (556):9-12. DOI: 10.1080/03655230600895259. View