Regioselective Cycloaddition of Trifluorodiazoethane with Electron-deficient Allenic Esters and Ketones: Access to CF3-substituted Pyrazolines and Pyrazoles

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2014 May 23

PMID 24850209

Citations 3

Authors

Fa-Guang Zhang

Yi Wei

Yu-Ping Yi

Jing Nie

Jun-An Ma

Affiliations

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Abstract

A highly regioselective cycloaddition procedure of electron-deficient allenes with trifluorodiazoethane (CF3CHN2) is described. In absence of bases, the reaction proceeded smoothly to give 5-(trifluoromethyl)pyrazolines, whereas the utility of Et3N led to the formation of 3-(trifluoromethyl)pyrazoles.

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