Positive and Negative Gustatory Inputs Affect Drosophila Lifespan Partly in Parallel to DFOXO Signaling

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2014 May 22

PMID 24847072

Citations 25

Authors

Ivan Ostojic

Werner Boll

Michael J Waterson

Tammy Chan

Rashmi Chandra

Scott D Pletcher

Joy Alcedo

Affiliations

Soon will be listed here.

Abstract

In Caenorhabditis elegans, a subset of gustatory neurons, as well as olfactory neurons, shortens lifespan, whereas a different subset of gustatory neurons lengthens it. Recently, the lifespan-shortening effect of olfactory neurons has been reported to be conserved in Drosophila. Here we show that the Drosophila gustatory system also affects lifespan in a bidirectional manner. We find that taste inputs shorten lifespan through inhibition of the insulin pathway effector dFOXO, whereas other taste inputs lengthen lifespan in parallel to this pathway. We also note that the gustatory influence on lifespan does not necessarily depend on food intake levels. Finally, we identify the nature of some of the taste inputs that could shorten versus lengthen lifespan. Together our data suggest that different gustatory cues can modulate the activities of distinct signaling pathways, including different insulin-like peptides, to promote physiological changes that ultimately affect lifespan.

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