Scott D Pletcher
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Explore the profile of Scott D Pletcher including associated specialties, affiliations and a list of published articles.
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80
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3732
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Recent Articles
1.
Fedina T, Cummins E, Promislow D, Pletcher S
Proc Natl Acad Sci U S A
. 2023 Dec;
120(51):e2308305120.
PMID: 38079545
The motivation to reproduce is a potent natural drive, and the social behaviors that induce it can severely impact animal health and lifespan. Indeed, in males, accelerated aging associated with...
2.
Weaver K, Raju S, Rucker R, Chakraborty T, Holt R, Pletcher S
Elife
. 2023 Jun;
12.
PMID: 37326496
Hunger is a motivational drive that promotes feeding, and it can be generated by the physiological need to consume nutrients as well as the hedonic properties of food. Brain circuits...
3.
Gendron C, Chakraborty T, Duran C, Dono T, Pletcher S
PLoS Biol
. 2023 Jun;
21(6):e3002149.
PMID: 37310911
Sensory perception modulates aging, yet we know little about how. An understanding of the neuronal mechanisms through which animals orchestrate biological responses to relevant sensory inputs would provide insight into...
4.
Johnson J, Munneke A, Richardson H, Gendron C, Pletcher S
Aging (Albany NY)
. 2023 Jan;
15(2):396-420.
PMID: 36622279
Across taxa, sensory perception modulates aging in response to important ecological cues, including food, sex, and danger. The range of sensory cues involved, and their mechanism of action, are largely...
5.
Munneke A, Chakraborty T, Porter S, Gendron C, Pletcher S
Front Aging
. 2022 Dec;
3:1068455.
PMID: 36531741
The conserved neurotransmitter serotonin has been shown to be an important modulator of lifespan in specific nutritional contexts; however, it remained unclear how serotonin signaling influences lifespan under normal conditions....
6.
Garratt M, Erturk I, Alonzo R, Zufall F, Leinders-Zufall T, Pletcher S, et al.
Elife
. 2022 Dec;
11.
PMID: 36525360
Several previous lines of research have suggested, indirectly, that mouse lifespan is particularly susceptible to endocrine or nutritional signals in the first few weeks of life, as tested by manipulations...
7.
Miller H, Huang S, Dean E, Schaller M, Tuckowski A, Munneke A, et al.
Nat Commun
. 2022 Jun;
13(1):3271.
PMID: 35672307
An organism's ability to perceive and respond to changes in its environment is crucial for its health and survival. Here we reveal how the most well-studied longevity intervention, dietary restriction,...
8.
Lyu Y, Promislow D, Pletcher S
Commun Biol
. 2021 Jun;
4(1):740.
PMID: 34131274
Aging arises from complex interactions among multiple biochemical products. Systems-level analyses of biological networks may provide insights into the causes and consequences of aging that evade single-gene studies. We have...
9.
Luo Y, Johnson J, Chakraborty T, Piontkowski A, Gendron C, Pletcher S
Sci Adv
. 2021 May;
7(20).
PMID: 33980491
Organisms make decisions based on the information they gather from their environment, the effects of which affect their fitness. Understanding how these interactions affect physiology may generate interventions that improve...
10.
Lyu Y, Weaver K, Shaukat H, Plumoff M, Tjilos M, Promislow D, et al.
Elife
. 2021 Jan;
10.
PMID: 33463526
It has been recognized for nearly a century that diet modulates aging. Despite early experiments suggesting that reduced caloric intake augmented lifespan, accumulating evidence indicates that other characteristics of the...