Functional Connectivity During Cognitive Control in Children with Autism Spectrum Disorder: an Independent Component Analysis

Overview

Journal J Neural Transm (Vienna)

Specialties Neurology
Physiology

Date 2014 May 22

PMID 24845879

Citations 10

Authors

S Ambrosino

D J Bos

T R van Raalten

N A Kobussen

J van Belle

B Oranje

S Durston

Affiliations

Soon will be listed here.

Abstract

Restrictive and repetitive behavior in autism may be related to deficits in cognitive control. Here, we aimed to assess functional connectivity during a cognitive control task and compare brain network activity and connectivity in children with autism spectrum disorders (ASD) and typically developing children using a multivariate data-driven approach. 19 high-functioning boys with ASD and 19 age-matched typically developing boys were included in this study. Functional magnetic resonance imaging was performed at 3T during the performance of a cognitive control task (go/no-go paradigm). Functional networks were identified using independent component analysis. Network activity and connectivity was compared between groups and correlated with clinical measures of rigid behavior using multivariate analysis of covariance. We found no differences between the groups in task performance or in network activity. Power analysis indicated that, if this were a real difference, it would require nearly 800 subjects to show group differences in network activity using this paradigm. Neither were there correlations between network activity and rigid behavior. Our data do not provide support for the presence of deficits in cognitive control in children with ASD, or the functional networks supporting this ability.

Citing Articles

Functional Networks Abnormalities in Autism Spectrum Disorder: Age-Related Hypo and Hyper Connectivity.

Haghighat H, Mirzarezaee M, Nadjar Araabi B, Khadem A Brain Topogr. 2021; 34(3):306-322.

PMID: 33905003 DOI: 10.1007/s10548-021-00831-7.

Comparative meta-analyses of brain structural and functional abnormalities during cognitive control in attention-deficit/hyperactivity disorder and autism spectrum disorder.

Lukito S, Norman L, Carlisi C, Radua J, Hart H, Simonoff E Psychol Med. 2020; 50(6):894-919.

PMID: 32216846 PMC: 7212063. DOI: 10.1017/S0033291720000574.

Building functional connectivity neuromarkers of behavioral self-regulation across children with and without Autism Spectrum Disorder.

Rohr C, Kamal S, Bray S Dev Cogn Neurosci. 2019; 41:100747.

PMID: 31826838 PMC: 6994646. DOI: 10.1016/j.dcn.2019.100747.

Rigidity coincides with reduced cognitive control to affective cues in children with autism.

Bos D, Silverman M, Ajodan E, Martin C, Silver B, Brouwer G J Abnorm Psychol. 2019; 128(5):431-441.

PMID: 31045398 PMC: 6617513. DOI: 10.1037/abn0000423.

No evidence of differences in cognitive control in children with autism spectrum disorder or obsessive-compulsive disorder: An fMRI study.

Gooskens B, Bos D, Mensen V, Shook D, Bruchhage M, Naaijen J Dev Cogn Neurosci. 2018; 36:100602.

PMID: 30559053 PMC: 6969278. DOI: 10.1016/j.dcn.2018.11.004.

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