Immune Diseases Caused by Mutations in Kinases and Components of the Ubiquitin System

Overview

Journal Nat Immunol

Date 2014 May 21

PMID 24840983

Citations 22

Authors

Philip Cohen

Affiliations

Soon will be listed here.

Abstract

The signaling networks that control the immune system are coordinated by a myriad of interconnecting phosphorylation and ubiquitylation events. This review provides an overview of mutations in human genes encoding these proteins that give rise to immune diseases. Analysis of the biological effects of these mutations has revealed the true physiological roles of particular signaling networks and promises to revolutionize the treatment of these diseases.

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