Therapies for Ataxias

Overview

Journal Curr Treat Options Neurol

Specialty Neurology

Date 2014 May 17

PMID 24832479

Citations 1

Authors

Laurence Martineau

Anne Noreau

Nicolas Dupre

Affiliations

Soon will be listed here.

Abstract

Ataxia can originate from many genetic defects, but also from nongenetic causes. To be able to provide treatment, the first step is to establish the right diagnosis. Once the cause of the ataxia is defined, some specific treatments may be available. For example, the nongenetic ataxias that arise from vitamin deficiencies can improve following treatment. In most cases, however, therapies do not cure the disease and are purely symptomatic. Physiotherapy and occupational therapy are effective in all type of ataxias and often remain the most efficient treatment option for these patients to maximize their quality of life.

Citing Articles

Novel SIL1 mutations cause cerebellar ataxia and atrophy in a French-Canadian family.

Noreau A, La Piana R, Marcoux C, Dion P, Brais B, Bernard G Neurogenetics. 2015; 16(4):315-8.

PMID: 26260654 DOI: 10.1007/s10048-015-0455-z.

References

Marmolino D, Acquaviva F . Friedreich's Ataxia: from the (GAA)n repeat mediated silencing to new promising molecules for therapy. Cerebellum. 2009; 8(3):245-59. DOI: 10.1007/s12311-008-0084-2. View

Chen S, Tsai N, Chang C, Lu C, Huang C, Chuang Y . Neuromuscular abnormality and autonomic dysfunction in patients with cerebrotendinous xanthomatosis. BMC Neurol. 2011; 11:63. PMC: 3119170. DOI: 10.1186/1471-2377-11-63. View

Jia D, Zhang L, Chen Z, Wang C, Huang F, Duan R . Lithium chloride alleviates neurodegeneration partly by inhibiting activity of GSK3β in a SCA3 Drosophila model. Cerebellum. 2013; 12(6):892-901. DOI: 10.1007/s12311-013-0498-3. View

Lorincz M . Recognition and treatment of neurologic Wilson's disease. Semin Neurol. 2013; 32(5):538-43. DOI: 10.1055/s-0033-1334476. View

Watase K, Gatchel J, Sun Y, Emamian E, Atkinson R, Richman R . Lithium therapy improves neurological function and hippocampal dendritic arborization in a spinocerebellar ataxia type 1 mouse model. PLoS Med. 2007; 4(5):e182. PMC: 1880853. DOI: 10.1371/journal.pmed.0040182. View

Di Gangi S, Gizzo S, Patrelli T, Saccardi C, DAntona D, Nardelli G . Wernicke's encephalopathy complicating hyperemesis gravidarum: from the background to the present. J Matern Fetal Neonatal Med. 2011; 25(8):1499-504. DOI: 10.3109/14767058.2011.629253. View

Nachbauer W, Boesch S, Schneider R, Eigentler A, Wanschitz J, Poewe W . Bioenergetics of the calf muscle in Friedreich ataxia patients measured by 31P-MRS before and after treatment with recombinant human erythropoietin. PLoS One. 2013; 8(7):e69229. PMC: 3726701. DOI: 10.1371/journal.pone.0069229. View

Pfeiffer R . Neurologic manifestations of malabsorption syndromes. Handb Clin Neurol. 2013; 120:621-32. DOI: 10.1016/B978-0-7020-4087-0.00042-5. View

Koeppen A . Friedreich's ataxia: pathology, pathogenesis, and molecular genetics. J Neurol Sci. 2011; 303(1-2):1-12. PMC: 3062632. DOI: 10.1016/j.jns.2011.01.010. View

10.

Marquer A, Barbieri G, Perennou D . The assessment and treatment of postural disorders in cerebellar ataxia: a systematic review. Ann Phys Rehabil Med. 2014; 57(2):67-78. DOI: 10.1016/j.rehab.2014.01.002. View

11.

Briani C, Torre C, Citton V, Manara R, Pompanin S, Binotto G . Cobalamin deficiency: clinical picture and radiological findings. Nutrients. 2013; 5(11):4521-39. PMC: 3847746. DOI: 10.3390/nu5114521. View

12.

Soragni E, Xu C, Plasterer H, Jacques V, Rusche J, Gottesfeld J . Rationale for the development of 2-aminobenzamide histone deacetylase inhibitors as therapeutics for Friedreich ataxia. J Child Neurol. 2012; 27(9):1164-73. PMC: 3743553. DOI: 10.1177/0883073812448533. View

13.

Brewer G . The use of copper-lowering therapy with tetrathiomolybdate in medicine. Expert Opin Investig Drugs. 2008; 18(1):89-97. DOI: 10.1517/13543780802621859. View

14.

Perlman S . A review of Friedreich ataxia clinical trial results. J Child Neurol. 2012; 27(9):1217-22. DOI: 10.1177/0883073812453872. View

15.

Gomes C, Santos R . Neurodegeneration in Friedreich's ataxia: from defective frataxin to oxidative stress. Oxid Med Cell Longev. 2013; 2013:487534. PMC: 3725840. DOI: 10.1155/2013/487534. View

16.

Browne D, Gancher S, Nutt J, Brunt E, Smith E, Kramer P . Episodic ataxia/myokymia syndrome is associated with point mutations in the human potassium channel gene, KCNA1. Nat Genet. 1994; 8(2):136-40. DOI: 10.1038/ng1094-136. View

17.

Guillaud O, Dumortier J, Sobesky R, Debray D, Wolf P, Vanlemmens C . Long term results of liver transplantation for Wilson's disease: experience in France. J Hepatol. 2013; 60(3):579-89. DOI: 10.1016/j.jhep.2013.10.025. View

18.

Grandas F, Garcia-Munozguren S, Anaya F . Early-onset parkinsonism in cerebrotendinous xanthomatosis. Mov Disord. 2002; 17(6):1396-7. DOI: 10.1002/mds.10287. View

19.

Maceyka M, Milstien S, Spiegel S . The potential of histone deacetylase inhibitors in Niemann - Pick type C disease. FEBS J. 2013; 280(24):6367-72. PMC: 3857996. DOI: 10.1111/febs.12505. View

20.

Becker D, Balcer L, Galetta S . The Neurological Complications of Nutritional Deficiency following Bariatric Surgery. J Obes. 2012; 2012:608534. PMC: 3432875. DOI: 10.1155/2012/608534. View