New Perspectives for Articular Cartilage Repair Treatment Through Tissue Engineering: A Contemporary Review

Overview

Journal World J Orthop

Publisher Baishideng Publishing Group

Specialty Orthopedics

Date 2014 May 16

PMID 24829869

Citations 42

Authors

Giuseppe Musumeci

Paola Castrogiovanni

Rosalia Leonardi

Francesca Maria Trovato

Marta Anna Szychlinska

Angelo Di Giunta

Carla Loreto

Sergio Castorina

Affiliations

Soon will be listed here.

Abstract

In this paper review we describe benefits and disadvantages of the established methods of cartilage regeneration that seem to have a better long-term effectiveness. We illustrated the anatomical aspect of the knee joint cartilage, the current state of cartilage tissue engineering, through mesenchymal stem cells and biomaterials, and in conclusion we provide a short overview on the rehabilitation after articular cartilage repair procedures. Adult articular cartilage has low capacity to repair itself, and thus even minor injuries may lead to progressive damage and osteoarthritic joint degeneration, resulting in significant pain and disability. Numerous efforts have been made to develop tissue-engineered grafts or patches to repair focal chondral and osteochondral defects, and to date several researchers aim to implement clinical application of cell-based therapies for cartilage repair. A literature review was conducted on PubMed, Scopus and Google Scholar using appropriate keywords, examining the current literature on the well-known tissue engineering methods for the treatment of knee osteoarthritis.

Citing Articles

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Immunohistochemical Analysis of Knee Chondral Defect Repair after Autologous Particulated Cartilage and Platelet-Rich Plasma Treatment in Sheep.

Alcaide-Ruggiero L, Molina-Hernandez V, Morgaz J, Fernandez-Sarmiento J, Granados M, Navarrete-Calvo R Int J Mol Sci. 2023; 24(20).

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The Current State of Osteoarthritis Treatment Options Using Stem Cells for Regenerative Therapy: A Review.

Thoene M, Bejer-Olenska E, Wojtkiewicz J Int J Mol Sci. 2023; 24(10).

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References

Musumeci G, Carnazza M, Leonardi R, Loreto C . Expression of β-defensin-4 in "an in vivo and ex vivo model" of human osteoarthritic knee meniscus. Knee Surg Sports Traumatol Arthrosc. 2011; 20(2):216-22. DOI: 10.1007/s00167-011-1630-x. View

Elisseeff J, McIntosh W, Anseth K, Riley S, Ragan P, Langer R . Photoencapsulation of chondrocytes in poly(ethylene oxide)-based semi-interpenetrating networks. J Biomed Mater Res. 2000; 51(2):164-71. DOI: 10.1002/(sici)1097-4636(200008)51:2<164::aid-jbm4>3.0.co;2-w. View

Miljkovic N, Cooper G, Marra K . Chondrogenesis, bone morphogenetic protein-4 and mesenchymal stem cells. Osteoarthritis Cartilage. 2008; 16(10):1121-30. DOI: 10.1016/j.joca.2008.03.003. View

Becerra J, Andrades J, Guerado E, Zamora-Navas P, Lopez-Puertas J, Reddi A . Articular cartilage: structure and regeneration. Tissue Eng Part B Rev. 2010; 16(6):617-27. DOI: 10.1089/ten.TEB.2010.0191. View

Gaissmaier C, Koh J, Weise K . Growth and differentiation factors for cartilage healing and repair. Injury. 2008; 39 Suppl 1:S88-96. DOI: 10.1016/j.injury.2008.01.035. View

Kerkhoffs G, Rowe B, Assendelft W, Kelly K, Struijs P, van Dijk C . Immobilisation for acute ankle sprain. A systematic review. Arch Orthop Trauma Surg. 2001; 121(8):462-71. DOI: 10.1007/s004020100283. View

Kang J, Chung C, Sung J, Park B, Choi J, Lee S . Novel porous matrix of hyaluronic acid for the three-dimensional culture of chondrocytes. Int J Pharm. 2008; 369(1-2):114-20. DOI: 10.1016/j.ijpharm.2008.11.008. View

Dorotka R, Windberger U, Macfelda K, Bindreiter U, Toma C, Nehrer S . Repair of articular cartilage defects treated by microfracture and a three-dimensional collagen matrix. Biomaterials. 2004; 26(17):3617-29. DOI: 10.1016/j.biomaterials.2004.09.034. View

Musumeci G, Castrogiovanni P, Loreto C, Castorina S, Pichler K, Weinberg A . Post-traumatic caspase-3 expression in the adjacent areas of growth plate injury site: a morphological study. Int J Mol Sci. 2013; 14(8):15767-84. PMC: 3759885. DOI: 10.3390/ijms140815767. View

10.

Musumeci G, Loreto C, Carnazza M, Cardile V, Leonardi R . Acute injury affects lubricin expression in knee menisci: an immunohistochemical study. Ann Anat. 2012; 195(2):151-8. DOI: 10.1016/j.aanat.2012.07.010. View

11.

Johnstone B, Alini M, Cucchiarini M, Dodge G, Eglin D, Guilak F . Tissue engineering for articular cartilage repair--the state of the art. Eur Cell Mater. 2013; 25:248-67. DOI: 10.22203/ecm.v025a18. View

12.

Masuda K, Sah R, Hejna M, Thonar E . A novel two-step method for the formation of tissue-engineered cartilage by mature bovine chondrocytes: the alginate-recovered-chondrocyte (ARC) method. J Orthop Res. 2003; 21(1):139-48. DOI: 10.1016/S0736-0266(02)00109-2. View

13.

Benz K, Breit S, Lukoschek M, Mau H, Richter W . Molecular analysis of expansion, differentiation, and growth factor treatment of human chondrocytes identifies differentiation markers and growth-related genes. Biochem Biophys Res Commun. 2002; 293(1):284-92. DOI: 10.1016/S0006-291X(02)00223-1. View

14.

Ameer G, Mahmood T, Langer R . A biodegradable composite scaffold for cell transplantation. J Orthop Res. 2002; 20(1):16-9. DOI: 10.1016/S0736-0266(01)00074-2. View

15.

Pichler K, Musumeci G, Vielgut I, Martinelli E, Sadoghi P, Loreto C . Towards a better understanding of bone bridge formation in the growth plate - an immunohistochemical approach. Connect Tissue Res. 2013; 54(6):408-15. DOI: 10.3109/03008207.2013.828715. View

16.

Vacanti J, Langer R . Tissue engineering: the design and fabrication of living replacement devices for surgical reconstruction and transplantation. Lancet. 1999; 354 Suppl 1:SI32-4. DOI: 10.1016/s0140-6736(99)90247-7. View

17.

Nejadnik H, Hui J, Feng Choong E, Tai B, Lee E . Autologous bone marrow-derived mesenchymal stem cells versus autologous chondrocyte implantation: an observational cohort study. Am J Sports Med. 2010; 38(6):1110-6. DOI: 10.1177/0363546509359067. View

18.

Hunziker E . Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. Osteoarthritis Cartilage. 2002; 10(6):432-63. DOI: 10.1053/joca.2002.0801. View

19.

Musumeci G, Loreto C, Carnazza M, Coppolino F, Cardile V, Leonardi R . Lubricin is expressed in chondrocytes derived from osteoarthritic cartilage encapsulated in poly (ethylene glycol) diacrylate scaffold. Eur J Histochem. 2011; 55(3):e31. PMC: 3203476. DOI: 10.4081/ejh.2011.e31. View

20.

Grad S, Eglin D, Alini M, Stoddart M . Physical stimulation of chondrogenic cells in vitro: a review. Clin Orthop Relat Res. 2011; 469(10):2764-72. PMC: 3171534. DOI: 10.1007/s11999-011-1819-9. View