[Sex Cord Gonadal Stromal Tumors]

Overview

Journal Pathologe

Specialty Pathology

Date 2014 May 14

PMID 24819979

Citations 4

Authors

F Bremmer

C L Behnes

H-J Radzun

M Bettstetter

S Schweyer

Affiliations

Soon will be listed here.

Abstract

According to the World Health Organization (WHO) classification from 2004, sex cord gonadal stromal tumors are divided into Leydig cell tumors, Sertoli cell tumors, granulosa cell tumors, tumors of the thecoma-fibroma group, incompletely differentiated sex cord gonadal stromal tumors, mixed forms of sex cord gonadal stromal tumors and tumors containing both germ cell and sex cord gonadal stromal elements. These tumors can appear sporadically or in combination with hereditary syndromes. To diagnose these rare tumors the combination of characteristic morphological aspects and various immunohistochemical markers is useful. Latest investigations demonstrate the potential role of mutation analyses in the diagnosis of this heterogeneous group of tumors.

Citing Articles

Myoid gonadal stromal tumor of the testis-the novel subtype of testicular gonadal stromal tumors: a case report and review of the literature.

Dieckmann K, Tharun L, Angerer M, Harms A, Wulfing C J Med Case Rep. 2024; 18(1):71.

PMID: 38383445 PMC: 10882757. DOI: 10.1186/s13256-024-04393-7.

The Value of MRI Findings Combined With Texture Analysis in the Differential Diagnosis of Primary Ovarian Granulosa Cell Tumors and Ovarian Thecoma-Fibrothecoma.

Li N, Shi B, Chen Y, Wang P, Wang C, Chen Y Front Oncol. 2021; 11:758036.

PMID: 34778075 PMC: 8578857. DOI: 10.3389/fonc.2021.758036.

Adult Granulosa Cell Tumor of the Testis: A Case Report with a Review of the Literature.

Dieckmann K, Bertolini J, Wulfing C Case Rep Urol. 2019; 2019:7156154.

PMID: 31236304 PMC: 6545753. DOI: 10.1155/2019/7156154.

[Leydig cell, Sertoli cell and adult granulosa cell tumors].

Bremmer F, Schweyer S Pathologe. 2016; 37(1):71-7.

PMID: 26782032 DOI: 10.1007/s00292-015-0131-y.

References

Bremmer F, Kessel F, Behnes C, Trojan L, Heinrich E . Leiomyoma of the tunica albuginea, a case report of a rare tumour of the testis and review of the literature. Diagn Pathol. 2012; 7:140. PMC: 3488515. DOI: 10.1186/1746-1596-7-140. View

Bianco B, Lipay M, Guedes A, Oliveira K, Verreschi I . SRY gene increases the risk of developing gonadoblastoma and/or nontumoral gonadal lesions in Turner syndrome. Int J Gynecol Pathol. 2009; 28(2):197-202. DOI: 10.1097/PGP.0b013e318186a825. View

Kaplan G, Cromie W, KELALIS P, Silber I, Tank Jr E . Gonadal stromal tumors: a report of the Prepubertal Testicular Tumor Registry. J Urol. 1986; 136(1 Pt 2):300-2. DOI: 10.1016/s0022-5347(17)44847-6. View

Kuroda N, Senzaki T, Yamasaki Y, Miyazaki E, Hayashi Y, Toi M . Sertoli cell tumor of the testis (not otherwise specified) with the expression of neuroendocrine markers and without the expression of inhibin-alpha. Pathol Int. 2004; 54(9):719-24. DOI: 10.1111/j.1440-1827.2004.01685.x. View

Ro J, Amin M, Tetu B, Ordonez N, Ayala A . Granulosa cell tumor of the adult testis: a clinicopathologic study of seven cases and a review of the literature. Hum Pathol. 1993; 24(10):1120-5. DOI: 10.1016/0046-8177(93)90193-k. View

Esber C, Shabsigh A, Zynger D . Sclerosing Sertoli cell tumor without expression of typical sex cord stromal tumor markers: case report and literature review. Pathol Res Pract. 2012; 208(2):121-5. DOI: 10.1016/j.prp.2011.11.007. View

Lima J, Jin L, de Araujo A, Erikson-Johnson M, Oliveira A, Sebo T . FOXL2 mutations in granulosa cell tumors occurring in males. Arch Pathol Lab Med. 2012; 136(7):825-8. DOI: 10.5858/arpa.2011-0355-OA. View

Halaszlaki C, Takacs I, Butz H, Patocs A, Lakatos P . Novel genetic mutation in the background of Carney complex. Pathol Oncol Res. 2012; 18(2):149-52. DOI: 10.1007/s12253-012-9502-3. View

Fragoso M, Latronico A, Carvalho F, Zerbini M, Marcondes J, Araujo L . Activating mutation of the stimulatory G protein (gsp) as a putative cause of ovarian and testicular human stromal Leydig cell tumors. J Clin Endocrinol Metab. 1998; 83(6):2074-8. DOI: 10.1210/jcem.83.6.4847. View

10.

Li Y, Vilain E, Conte F, Rajpert-De Meyts E, Lau Y . Testis-specific protein Y-encoded gene is expressed in early and late stages of gonadoblastoma and testicular carcinoma in situ. Urol Oncol. 2007; 25(2):141-6. DOI: 10.1016/j.urolonc.2006.08.002. View

11.

Efthimiou I, Mamoulakis C, Papageorgiou G, Kazoulis S, Prevedorou D, Kontogiorgos G . Unilateral malignant leydig cell tumor of testis in a patient with contralateral cryptorchidism. Urol J. 2009; 6(1):60-2. View

12.

Haas G, Pittaluga S, Gomella L, Travis W, Sherins R, Doppman J . Clinically occult Leydig cell tumor presenting with gynecomastia. J Urol. 1989; 142(5):1325-7. DOI: 10.1016/s0022-5347(17)39077-8. View

13.

Cheville J, Sebo T, Lager D, Bostwick D, Farrow G . Leydig cell tumor of the testis: a clinicopathologic, DNA content, and MIB-1 comparison of nonmetastasizing and metastasizing tumors. Am J Surg Pathol. 1998; 22(11):1361-7. DOI: 10.1097/00000478-199811000-00006. View

14.

Perrone F, Bertolotti A, Montemurro G, Paolini B, Pierotti M, Colecchia M . Frequent mutation and nuclear localization of β-catenin in sertoli cell tumors of the testis. Am J Surg Pathol. 2013; 38(1):66-71. DOI: 10.1097/PAS.0b013e31829cdbc6. View

15.

Liu G, Duranteau L, Carel J, Monroe J, Doyle D, Shenker A . Leydig-cell tumors caused by an activating mutation of the gene encoding the luteinizing hormone receptor. N Engl J Med. 1999; 341(23):1731-6. DOI: 10.1056/NEJM199912023412304. View

16.

Young R, Koelliker D, Scully R . Sertoli cell tumors of the testis, not otherwise specified: a clinicopathologic analysis of 60 cases. Am J Surg Pathol. 1998; 22(6):709-21. DOI: 10.1097/00000478-199806000-00008. View

17.

Collins D, Symington T . SERTOLI-CELL TUMOUR. Br J Urol. 1964; 36:SUPPL:52-61. View

18.

Bertram K, Bratloff B, Hodges G, Davidson H . Treatment of malignant Leydig cell tumor. Cancer. 1991; 68(10):2324-9. DOI: 10.1002/1097-0142(19911115)68:10<2324::aid-cncr2820681036>3.0.co;2-k. View

19.

Petersson F, Bulimbasic S, Sima R, Michal M, Hora M, Malagon H . Large cell calcifying Sertoli cell tumor: a clinicopathologic study of 1 malignant and 3 benign tumors using histomorphology, immunohistochemistry, ultrastructure, comparative genomic hybridization, and polymerase chain reaction analysis of the.... Hum Pathol. 2009; 41(4):552-9. DOI: 10.1016/j.humpath.2009.09.008. View

20.

Davis J, Woodroof J, Sadasivan R, Stephens R . Case report: congenital adrenal hyperplasia and malignant Leydig cell tumor. Am J Med Sci. 1995; 309(1):63-5. DOI: 10.1097/00000441-199501000-00010. View