Therapeutic Potential of HO-1 in Autoimmune Diseases

Overview

Journal Inflammation

Specialties Allergy & Immunology
Pathology

Date 2014 May 14

PMID 24818708

Citations 18

Authors

Bao-Zhu Li

Biao Guo

Hai-Yan Zhang

Juan Liu

Sha-Sha Tao

Hai-Feng Pan

Dong-Qing Ye

Affiliations

Soon will be listed here.

Abstract

Heme oxygenase-1 (HO-1), the inducible isoform of heme oxygenase (HO), has raised a lot of concerns in recent years due to its multiple functions. HO-1 was found to be a pivotal cytoprotective, antioxidant, anti-apoptotic, immunosuppressive, as well as anti-inflammatory molecule. Recent studies have clarified its significant functions in many diseases with substantial findings. In autoimmune diseases, HO-1 may have promising therapeutic potential. Here, we briefly reviewed recent advances in this field, aiming at hopefully exploring the potential therapeutic roles of HO-1, and design HO-1-based strategies for the treatment of autoimmune diseases.

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