Eosinophils in Hereditary and Inflammatory Myopathies

Overview

Journal Acta Myol

Date 2014 May 8

PMID 24803842

Citations 16

Authors

Thomas Schroder

Johann Fuchss

Ilka Schneider

Gisela Stoltenburg-Didinger

Frank Hanisch

Affiliations

Soon will be listed here.

Abstract

It is not known whether eosinophilic myositis is a specific histopathological feature of limb girdle muscular dystrophy 2A (LGMD2A). Number and location of eosinophils in skeletal muscle biopsies (n=100) was analysed by Giemsa and modified hematoxylin/eosin staining in patients with genetically confirmed myopathies (LGMD2A, LGMD2B, LGMD2L, facioscapulohumeral muscular dystrophy, dystrophinopathy), histologically confirmed idiopathic inflammatory myopathies (sporadic inclusion body myositis (sIBM), dermatomyositis (DM), polymyositis), amyotrophic lateral sclerosis (neurogenic control), and normal controls. The number of eosinophils/mm² was significantly higher in LGMD2A, PM, DM, and sIBM compared to controls but not significantly higher than other myopathies. A large overlap in the number of eosinophils/mm2 between all groups was seen. In all disease groups eosinophils were mainly found endomysially (46- 88%) and intra- and perivascularly (4-37%). There was no correlation between the numbers of eosinophils/mm² and (i) age at biopsy and (ii) the duration of the disease. The extent of myopathic, fibrotic, and inflammatory changes did not differ in samples with high and low eosinophil count. Eosinophils seem to represent an unspecific histological finding in hereditary and inflammatory myopathies, but also amyotrophic lateral sclerosis.

Citing Articles

Development of differential diagnostic models for distinguishing between limb-girdle muscular dystrophy and idiopathic inflammatory myopathy.

Wang G, Fu L, Zhang L, Shao K, Hou Y, Dai T Arthritis Res Ther. 2024; 26(1):215.

PMID: 39695751 PMC: 11658350. DOI: 10.1186/s13075-024-03458-8.

Eosinophilic Orbital Myositis Superseding Ocular Myasthenia.

El Hasbani G, Tarhini A, Wehbe R, Ghieh D, Farhat L, Uthman I Mediterr J Rheumatol. 2024; 35(1):192-194.

PMID: 38736949 PMC: 11082768. DOI: 10.31138/mjr.150523.eom.

Eosinophilic enterocolitis in duodenum, ileum, and colon: A case report.

Van-Londono I, Ramirez-Giraldo C, Martinez Echeverri J, Villany-Sarmiento J, Fino-Velasquez L Heliyon. 2024; 10(5):e26885.

PMID: 38468951 PMC: 10925976. DOI: 10.1016/j.heliyon.2024.e26885.

Muscle eosinophilia is a hallmark of chronic disease in facioscapulohumeral muscular dystrophy.

Nunes A, Ramirez M, Garcia-Collazo E, Jones T, Jones P Hum Mol Genet. 2024; 33(10):872-883.

PMID: 38340007 PMC: 11070135. DOI: 10.1093/hmg/ddae019.

Compositional and Functional MRI of Skeletal Muscle: A Review.

Hooijmans M, Schlaffke L, Bolsterlee B, Schlaeger S, Marty B, Mazzoli V J Magn Reson Imaging. 2023; 60(3):860-877.

PMID: 37929681 PMC: 11070452. DOI: 10.1002/jmri.29091.

References

Xu X, Rivkind A, Pikarsky A, Pappo O, Bischoff S, Levi-Schaffer F . Mast cells and eosinophils have a potential profibrogenic role in Crohn disease. Scand J Gastroenterol. 2004; 39(5):440-7. DOI: 10.1080/00365520310008566. View

Jankowski R, Persoons M, Foliguet B, Coffinet L, Thomas C . Eosinophil count in nasal secretions of subjects with and without nasal symptoms. Rhinology. 2000; 38(1):23-32. View

Chao C, Hsieh S, Shun C, Hsieh S . Skin denervation and cutaneous vasculitis in eosinophilia-associated neuropathy. Arch Neurol. 2007; 64(7):959-65. DOI: 10.1001/archneur.64.7.959. View

Brooks B, Miller R, Swash M, Munsat T . El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord. 2001; 1(5):293-9. DOI: 10.1080/146608200300079536. View

Walsh M, Curran D, Kingham P, Morgan R, Durcan N, Gleich G . Effect of eosinophil adhesion on intracellular signaling in cholinergic nerve cells. Am J Respir Cell Mol Biol. 2003; 30(3):333-41. DOI: 10.1165/rcmb.2003-0188OC. View

Fanin M, Nardetto L, Nascimbeni A, Tasca E, Spinazzi M, Padoan R . Correlations between clinical severity, genotype and muscle pathology in limb girdle muscular dystrophy type 2A. J Med Genet. 2007; 44(10):609-14. PMC: 2597960. DOI: 10.1136/jmg.2007.050328. View

Brady S, Squier W, Hilton-Jones D . Clinical assessment determines the diagnosis of inclusion body myositis independently of pathological features. J Neurol Neurosurg Psychiatry. 2013; 84(11):1240-6. DOI: 10.1136/jnnp-2013-305690. View

Kumamoto T, Ueyama H, Fujimoto S, Nagao S, Tsuda T . Clinicopathologic characteristics of polymyositis patients with numerous tissue eosinophils. Acta Neurol Scand. 1996; 94(2):110-4. DOI: 10.1111/j.1600-0404.1996.tb07039.x. View

Meyerholz D, Griffin M, Castilow E, Varga S . Comparison of histochemical methods for murine eosinophil detection in an RSV vaccine-enhanced inflammation model. Toxicol Pathol. 2009; 37(2):249-55. PMC: 2664312. DOI: 10.1177/0192623308329342. View

10.

Weinstock A, Green C, Cohen B, Prayson R . Becker muscular dystrophy presenting as eosinophilic inflammatory myopathy in an infant. J Child Neurol. 1997; 12(2):146-7. DOI: 10.1177/088307389701200214. View

11.

Janin A . Eosinophilic myocarditis and fibrosis. Hum Pathol. 2005; 36(5):592-3. DOI: 10.1016/j.humpath.2005.03.001. View

12.

Cantarini L, Volpi N, Carbotti P, Greco G, Agliano M, Bellisai F . Eosinophilia-associated muscle disorders: an immunohistological study with tissue localisation of major basic protein in distinct clinicopathological forms. J Clin Pathol. 2009; 62(5):442-7. DOI: 10.1136/jcp.2008.060616. View

13.

Hanisch F, Muller C, Grimm D, Xue L, Traufeller K, Merkenschlager A . Frequency of calpain-3 c.550delA mutation in limb girdle muscular dystrophy type 2 and isolated hyperCKemia in German patients. Clin Neuropathol. 2007; 26(4):157-63. DOI: 10.5414/npp26157. View

14.

Sugihara R, Kumamoto T, Ito T, Ueyama H, Toyoshima I, Tsuda T . Human muscle protein degradation in vitro by eosinophil cationic protein (ECP). Muscle Nerve. 2001; 24(12):1627-34. DOI: 10.1002/mus.1198. View

15.

Hall F, Krausz T, Walport M . Idiopathic eosinophilic myositis. QJM. 1995; 88(8):581-6. View

16.

Murata K, Sugie K, Takamure M, Fujimoto T, Ueno S . Eosinophilic major basic protein and interleukin-5 in eosinophilic myositis. Eur J Neurol. 2003; 10(1):35-8. DOI: 10.1046/j.1468-1331.2003.00481.x. View

17.

Wehling-Henricks M, Sokolow S, Lee J, Myung K, Villalta S, Tidball J . Major basic protein-1 promotes fibrosis of dystrophic muscle and attenuates the cellular immune response in muscular dystrophy. Hum Mol Genet. 2008; 17(15):2280-92. PMC: 2574717. DOI: 10.1093/hmg/ddn129. View

18.

Titlic M, Kodzoman K, Loncar D . Neurologic manifestations of hypereosinophilic syndrome--review of the literature. Acta Clin Croat. 2012; 51(1):65-9. View

19.

Amato A . Adults with eosinophilic myositis and calpain-3 mutations. Neurology. 2008; 70(9):730-1. DOI: 10.1212/01.wnl.0000287138.89373.6b. View

20.

Noguchi H, Kephart G, Colby T, Gleich G . Tissue eosinophilia and eosinophil degranulation in syndromes associated with fibrosis. Am J Pathol. 1992; 140(2):521-8. PMC: 1886427. View