The Transmembrane Channel-like Protein Family and Human Papillomaviruses: Insights into Epidermodysplasia Verruciformis and Progression to Squamous Cell Carcinoma

Overview

Journal Oncoimmunology

Specialty Allergy & Immunology

Date 2014 May 7

PMID 24800179

Citations 5

Authors

Jaime S Horton

Alexander J Stokes

Affiliations

Soon will be listed here.

Abstract

(EV) is a rare genodermatosis characterized by increased sensitivity to infection by the β-subtype of human papillomaviruses (β-HPVs), causing persistent, tinea versicolor-like dermal lesions. In a majority of affected individuals, these macular lesions progress to invasive cutaneous squamous cell carcinoma (CSCC) in sun-exposed areas. While mutations in transmembrane channel-like 6 () and 8 () have been causally linked to EV, their molecular functions are unclear. It is likely that their protective effects involve regulation of the β-HPV life cycle, host keratinocyte apoptosis vs. survival balance and/or T-cell interaction with infected host cells.

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