Mst1/2 Signalling to Yap: Gatekeeper for Liver Size and Tumour Development

Overview

Journal Br J Cancer

Specialty Oncology

Date 2010 Nov 25

PMID 21102585

Citations 61

Authors

J Avruch

D Zhou

J Fitamant

N Bardeesy

Affiliations

Soon will be listed here.

Abstract

The mechanisms controlling mammalian organ size have long been a source of fascination for biologists. These controls are needed to both ensure the integrity of the body plan and to restrict inappropriate proliferation that could lead to cancer. Regulation of liver size is of particular interest inasmuch as this organ maintains the capacity for regeneration throughout life, and is able to regain precisely its original mass after partial surgical resection. Recent studies using genetically engineered mouse strains have shed new light on this problem; the Hippo signalling pathway, first elucidated as a regulator of organ size in Drosophila, has been identified as dominant determinant of liver growth. Defects in this pathway in mouse liver lead to sustained liver overgrowth and the eventual development of both major types of liver cancer, hepatocellular carcinoma and cholangiocarcinoma. In this review, we discuss the role of Hippo signalling in liver biology and the contribution of this pathway to liver cancer in humans.

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