A New Single Nucleotide Polymorphism in the Rabbit (Oryctolagus Cuniculus) Myostatin (MSTN) Gene is Associated with Carcass Composition Traits

Overview

Journal Anim Genet

Specialties Biology
Genetics

Date 2014 May 7

PMID 24796976

Citations 8

Authors

Ina Sternstein

Monika Reissmann

Dorota Maj

Josef Bieniek

Gudrun A Brockmann

Affiliations

Soon will be listed here.

Abstract

This study aimed at the identification of genetic variations in the myostatin (MSTN) gene and testing their effects on carcass quality traits. We comparatively sequenced Giant Grey (GG) and New Zealand White (NZW) rabbits that were founders of a cross-bred population. Alignment of our sequence data with the GenBank sequence of the rabbit MSTN gene (Ensembl Gene ID ENSOCUG00000012663) identified three single nucleotide polymorphisms (SNPs). The two novel SNPs (c.-125T>C, c.373+234G>A) and one known SNP (c.747+34C>T) were subsequently analysed for linkage with carcass composition traits in 363 F2 animals of the cross GG × NZW. Significant linkage was found between c.373+234G>A and nine carcass composition traits (P < 0.05). No significant effects were found for c.-125T>C and c.747+34C>T. Because the linked SNP is located in intron 1 and no genetic variation was found in the coding region, further investigations are necessary to understand the functional effect of the c.373+234G>A variant on the variability of the traits.

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