Effect of Low-magnitude Whole-body Vibration Combined with Alendronate in Ovariectomized Rats: a Random Controlled Osteoporosis Prevention Study

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 May 7

PMID 24796785

Citations 17

Authors

Guo-Xian Chen

Shuai Zheng

Shuai Qin

Zhao-Ming Zhong

Xiu-Hua Wu

Zhi-Ping Huang

Wei Li

Ruo-Ting Ding

Hui Yu

Jian-Ting Chen

Affiliations

Soon will be listed here.

Abstract

Background: Alendronate (ALE) is a conventional drug used to treat osteoporosis. Low-magnitude whole-body vibration (WBV) exercise has been developed as a potential treatment for osteoporosis. The aim of this study was to investigate whether low-magnitude WBV could enhance the protective effect of ALE on bone properties in ovariectomized rats.

Methods: A total of 128 Sprague-Dawley rats were randomly divided into five groups (SHAM, OVX+VEH, OVX+WBV, OVX + ALE, OVX+WBV+ALE). The level of WBV applied was 0.3 g at 45-55 Hz for 20 min/day, 5 day/week and for 3 months. ALE was administered in dose of 1 mg/Kg once a week. Every four weeks eight rats from each group were sacrificed and their blood and both tibiae were harvested. The expression of osteocalcin and CTX in serum was measured by enzyme-linked immunosorbent assay (ELISA) and the tibiae were subjected to metaphyseal three-point bending and μCT analysis.

Results: Osteocalcin rose after ovariectomy and was not appreciably changed by either alendronate or WBV alone or in combination. Alendronate treatment significantly prevented an increase in CTX. WBV alone treatment did not alter this effect. Compared with the OVX+WBV group, nearly all tested indices such as the BV/TV, TV apparent, Tb.N, Tb.Th, and Conn.D were higher in the OVX+ALE group at week 12.Compared with the OVX+WBV group, certain tested indices such as BV/TV, TV apparent, Tb.N, and Con.D, were higher in the OVX+WBV+ALE group at week 12. At week 12, tibiae treated with WBV+ALE exhibited a significantly higher Fmax compared to the OVX+VEH group, and a significant difference was also found in energy absorption between the OVX+WBV+ALE and OVX+VEH groups.

Conclusions: Compared with the WBV, ALE was more effective at preventing bone loss and improved the trabecular architecture. However, WBV enhanced the effect of alendronate in ovariectomized rats by inducing further improvements in trabecular architecture.

Citing Articles

Whole Body Vibration: A Valid Alternative Strategy to Exercise?.

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Effects of whole body vibration on bone properties in growing rats.

Minematsu A, Nishii Y Int Biomech. 2022; 9(1):19-26.

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The Effects of Whole-Body Vibration Exercise Combined With an Isocaloric High-Fructose Diet on Osteoporosis and Immunomodulation in Ovariectomized Mice.

Tsai S, Tseng Y, Chiou W, Chen S, Chung Y, Wei W Front Nutr. 2022; 9:915483.

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Effect of 50-Hertz Sinusoidal Vibration on the Uterus in Ovariectomy-Induced Osteoporotic Rats.

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The Potential Mechanism of Exercise Combined with Natural Extracts to Prevent and Treat Postmenopausal Osteoporosis.

Zhou T, Gai Z, Gao X, Li L J Healthc Eng. 2021; 2021:2852661.

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