The Effect of Low-magnitude, High-frequency Vibration on Poly(ethylene Glycol)-microencapsulated Mesenchymal Stem Cells

Overview

Journal J Tissue Eng

Date 2018 Sep 25

PMID 30245801

Citations 7

Authors

Sneha Mehta

Brooke McClarren

Ayesha Aijaz

Rabab Chalaby

Kimberly Cook-Chennault

Ronke M Olabisi

Affiliations

Soon will be listed here.

Abstract

Low-magnitude, high-frequency vibration has stimulated osteogenesis in mesenchymal stem cells when these cells were cultured in certain types of three-dimensional environments. However, results of osteogenesis are conflicting with some reports showing no effect of vibration at all. A large number of vibration studies using three-dimensional scaffolds employ scaffolds derived from natural sources. Since these natural sources potentially have inherent biochemical and microarchitectural cues, we explored the effect of low-magnitude, high-frequency vibration at low, medium, and high accelerations when mesenchymal stem cells were encapsulated in poly(ethylene glycol) diacrylate microspheres. Low and medium accelerations enhanced osteogenesis in mesenchymal stem cells while high accelerations inhibited it. These studies demonstrate that the isolated effect of vibration alone induces osteogenesis.

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References

Leung K, Shi H, Cheung W, Qin L, Ng W, Tam K . Low-magnitude high-frequency vibration accelerates callus formation, mineralization, and fracture healing in rats. J Orthop Res. 2008; 27(4):458-65. DOI: 10.1002/jor.20753. View

Mathieu P, Loboa E . Cytoskeletal and focal adhesion influences on mesenchymal stem cell shape, mechanical properties, and differentiation down osteogenic, adipogenic, and chondrogenic pathways. Tissue Eng Part B Rev. 2012; 18(6):436-44. PMC: 3495119. DOI: 10.1089/ten.TEB.2012.0014. View

Bartholomew A, Sturgeon C, Siatskas M, Ferrer K, McIntosh K, Patil S . Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol. 2002; 30(1):42-8. DOI: 10.1016/s0301-472x(01)00769-x. View

Chen Y, Huang C, Lee I, Lee Y, Chen M, Young T . Effects of cyclic mechanical stretching on the mRNA expression of tendon/ligament-related and osteoblast-specific genes in human mesenchymal stem cells. Connect Tissue Res. 2008; 49(1):7-14. DOI: 10.1080/03008200701818561. View

Xie L, Rubin C, Judex S . Enhancement of the adolescent murine musculoskeletal system using low-level mechanical vibrations. J Appl Physiol (1985). 2008; 104(4):1056-62. DOI: 10.1152/japplphysiol.00764.2007. View

Zhou Y, Guan X, Zhu Z, Gao S, Zhang C, Li C . Osteogenic differentiation of bone marrow-derived mesenchymal stromal cells on bone-derived scaffolds: effect of microvibration and role of ERK1/2 activation. Eur Cell Mater. 2011; 22:12-25. DOI: 10.22203/ecm.v022a02. View

Slatkovska L, Alibhai S, Beyene J, Hu H, Demaras A, Cheung A . Effect of 12 months of whole-body vibration therapy on bone density and structure in postmenopausal women: a randomized trial. Ann Intern Med. 2011; 155(10):668-79, W205. DOI: 10.7326/0003-4819-155-10-201111150-00005. View

Edwards J, Reilly G . Vibration stimuli and the differentiation of musculoskeletal progenitor cells: Review of results in vitro and in vivo. World J Stem Cells. 2015; 7(3):568-82. PMC: 4404392. DOI: 10.4252/wjsc.v7.i3.568. View

Chan M, Adler B, Green D, Rubin C . Bone structure and B-cell populations, crippled by obesity, are partially rescued by brief daily exposure to low-magnitude mechanical signals. FASEB J. 2012; 26(12):4855-63. PMC: 3509057. DOI: 10.1096/fj.12-209841. View

10.

Dawson E, Mapili G, Erickson K, Taqvi S, Roy K . Biomaterials for stem cell differentiation. Adv Drug Deliv Rev. 2007; 60(2):215-28. DOI: 10.1016/j.addr.2007.08.037. View

11.

von Stengel S, Kemmler W, Engelke K, Kalender W . Effects of whole body vibration on bone mineral density and falls: results of the randomized controlled ELVIS study with postmenopausal women. Osteoporos Int. 2010; 22(1):317-25. DOI: 10.1007/s00198-010-1215-4. View

12.

Porter J, Ruckh T, Popat K . Bone tissue engineering: a review in bone biomimetics and drug delivery strategies. Biotechnol Prog. 2009; 25(6):1539-60. DOI: 10.1002/btpr.246. View

13.

Uzer G, Pongkitwitoon S, Ian C, Thompson W, Rubin J, Chan M . Gap junctional communication in osteocytes is amplified by low intensity vibrations in vitro. PLoS One. 2014; 9(3):e90840. PMC: 3948700. DOI: 10.1371/journal.pone.0090840. View

14.

Aijaz A, Faulknor R, Berthiaume F, Olabisi R . Hydrogel Microencapsulated Insulin-Secreting Cells Increase Keratinocyte Migration, Epidermal Thickness, Collagen Fiber Density, and Wound Closure in a Diabetic Mouse Model of Wound Healing. Tissue Eng Part A. 2015; 21(21-22):2723-32. PMC: 4652158. DOI: 10.1089/ten.TEA.2015.0069. View

15.

Shi H, Cheung W, Qin L, Leung A, Leung K . Low-magnitude high-frequency vibration treatment augments fracture healing in ovariectomy-induced osteoporotic bone. Bone. 2009; 46(5):1299-305. DOI: 10.1016/j.bone.2009.11.028. View

16.

Hwang S, Song Y, Cho T, Kim R, Lee T, Kim S . The implications of the response of human mesenchymal stromal cells in three-dimensional culture to electrical stimulation for tissue regeneration. Tissue Eng Part A. 2011; 18(3-4):432-45. DOI: 10.1089/ten.tea.2010.0752. View

17.

Pedersen J, Swartz M . Mechanobiology in the third dimension. Ann Biomed Eng. 2005; 33(11):1469-90. DOI: 10.1007/s10439-005-8159-4. View

18.

Verschueren S, Roelants M, Delecluse C, Swinnen S, Vanderschueren D, Boonen S . Effect of 6-month whole body vibration training on hip density, muscle strength, and postural control in postmenopausal women: a randomized controlled pilot study. J Bone Miner Res. 2004; 19(3):352-9. DOI: 10.1359/JBMR.0301245. View

19.

Vanleene M, Shefelbine S . Therapeutic impact of low amplitude high frequency whole body vibrations on the osteogenesis imperfecta mouse bone. Bone. 2013; 53(2):507-14. PMC: 3590448. DOI: 10.1016/j.bone.2013.01.023. View

20.

Castillo A, Alam I, Tanaka S, Levenda J, Li J, Warden S . Low-amplitude, broad-frequency vibration effects on cortical bone formation in mice. Bone. 2006; 39(5):1087-1096. DOI: 10.1016/j.bone.2006.04.026. View