Radon Inhalation Protects Against Transient Global Cerebral Ischemic Injury in Gerbils

Overview

Journal Inflammation

Specialties Allergy & Immunology
Pathology

Date 2014 May 6

PMID 24792782

Citations 7

Authors

Takahiro Kataoka

Reo Etani

Yuji Takata

Yuichi Nishiyama

Atsushi Kawabe

Masayuki Kumashiro

Takehito Taguchi

Kiyonori Yamaoka

Affiliations

Soon will be listed here.

Abstract

Although brain disorders are not the main indication for radon therapy, our previous study suggested that radon inhalation therapy might mitigate brain disorders. In this study, we assessed whether radon inhalation protects against transient global cerebral ischemic injury in gerbils. Gerbils were treated with inhaled radon at a concentration of 2,000 Bq/m(3) for 24 h. After radon inhalation, transient global cerebral ischemia was induced by bilateral occlusion of the common carotid artery. Results showed that transient global cerebral ischemia induced neuronal damage in hippocampal CA1, and the number of damaged neurons was significantly increased compared with control. However, radon treatment inhibited ischemic damage. Superoxide dismutase (SOD) activity in the radon-treated gerbil brain was significantly higher than that in sham-operated gerbils. These findings suggested that radon inhalation activates antioxidative function, especially SOD, thereby inhibiting transient global cerebral ischemic injury in gerbils.

Citing Articles

Confirmation of efficacy, elucidation of mechanism, and new search for indications of radon therapy.

Yamaoka K, Kataoka T J Clin Biochem Nutr. 2022; 70(2):87-92.

PMID: 35400814 PMC: 8921726. DOI: 10.3164/jcbn.21-85.

Evaluation of the redox state in mouse organs following radon inhalation.

Kataoka T, Kanzaki N, Sakoda A, Shuto H, Yano J, Naoe S J Radiat Res. 2021; 62(2):206-216.

PMID: 33503655 PMC: 7948851. DOI: 10.1093/jrr/rraa129.

Radon Exposure-Therapeutic Effect and Cancer Risk.

Maier A, Wiedemann J, Rapp F, Papenfuss F, Rodel F, Hehlgans S Int J Mol Sci. 2021; 22(1).

PMID: 33396815 PMC: 7796069. DOI: 10.3390/ijms22010316.

X-Irradiation at 0.5 Gy after the forced swim test reduces forced swimming-induced immobility in mice.

Kataoka T, Shuto H, Yano J, Naoe S, Ishida T, Nakada T J Radiat Res. 2020; 61(4):517-523.

PMID: 32346734 PMC: 7336566. DOI: 10.1093/jrr/rraa022.

Radon inhalation induces manganese-superoxide dismutase in mouse brain via nuclear factor-κB activation.

Kataoka T, Etani R, Kanzaki N, Kobashi Y, Yunoki Y, Ishida T J Radiat Res. 2017; 58(6):887-893.

PMID: 28992350 PMC: 5710606. DOI: 10.1093/jrr/rrx048.

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