ACE Overexpression in Myelomonocytic Cells: Effect on a Mouse Model of Alzheimer's Disease

Overview

Journal Curr Hypertens Rep

Specialty Cardiology & Vascular Diseases

Date 2014 May 6

PMID 24792094

Citations 10

Authors

Maya Koronyo-Hamaoui

Kandarp Shah

Yosef Koronyo

Ellen Bernstein

Jorge F Giani

Tea Janjulia

Keith L Black

Peng D Shi

Romer A Gonzalez-Villalobos

Sebastien Fuchs

Xiao Z Shen

Kenneth E Bernstein

Affiliations

Soon will be listed here.

Abstract

While it is well known that angiotensin converting enzyme (ACE) plays an important role in blood pressure control, ACE also has effects on renal function, hematopoiesis, reproduction, and aspects of the immune response. ACE 10/10 mice overexpress ACE in myelomonocytic cells. Macrophages from these mice have an increased polarization towards a pro-inflammatory phenotype that results in a very effective immune response to challenge by tumors or bacterial infection. In a mouse model of Alzheimer's disease (AD), the ACE 10/10 phenotype provides significant protection against AD pathology, including reduced inflammation, reduced burden of the neurotoxic amyloid-β protein and preserved cognitive function. Taken together, these studies show that increased myelomonocytic ACE expression in mice alters the immune response to better defend against many different types of pathologic insult, including the cognitive decline observed in an animal model of AD.

Citing Articles

Proteomic Analysis of Human Macrophages Overexpressing Angiotensin-Converting Enzyme.

Oosthuizen D, Ganief T, Bernstein K, Sturrock E Int J Mol Sci. 2024; 25(13).

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Identification of blood metabolites associated with risk of Alzheimer's disease by integrating genomics and metabolomics data.

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The effects of enhancing angiotensin converting enzyme in myelomonocytes on ameliorating Alzheimer's-related disease and preserving cognition.

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Screening for urinary markers predicting hematopoietic stem cell injury induced by busulfan using genetically diverse mice.

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