Prevalence of Obesity, Hyperlipemia and Insulin Resistance in Children with Suprasellar Brain Tumors

Overview

Journal Clin Pediatr Endocrinol

Specialty Pediatrics

Date 2014 May 3

PMID 24790338

Citations 9

Authors

Masanori Adachi

Takayoshi Tsuchiya

Koji Muroya

Yumi Asakura

Ken-Ichi Sekido

Hironobu Sato

Affiliations

Soon will be listed here.

Abstract

Weight gain is a common sequela of suprasellar tumors, referred to as hypothalamic obesity. We undertook an evaluation of obesity and metabolic aberrations among patients treated at our institute. During the 12 mo from Apr. 2005, 23 patients (10 males and 13 females) with remitted suprasellar tumors attended our clinic: 10 patients with craniopharyngioma, 7 with germinoma, 4 with optic nerve glioma and others. Of these, 12 patients (52%) were found to have obesity on the basis of percent overweight and/or percent body fat. Elevated cholesterol and/or triglyceride (TG) was found in 9 patients (39%), and insulin resistance was suspected in 7 patients (30%). Three patients exhibited strikingly elevated postprandial TG levels. All 6 patients with the growth without GH phenomenon had at least one metabolic aberration. In conclusion, the prevalence of hypothalamic obesity was nearly half in our series, and hyperlipemia and insulin resistance were also frequently found. The increased risk for metabolic aberration in growth without GH patients was suggested.

Citing Articles

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