Role of Pancreatic Stellate Cells in Chemoresistance in Pancreatic Cancer

Overview

Journal Front Physiol

Date 2014 May 1

PMID 24782785

Citations 75

Authors

Joshua A McCarroll

Stephanie Naim

George Sharbeen

Nelson Russia

Julia Lee

Maria Kavallaris

David Goldstein

Phoebe A Phillips

Affiliations

Soon will be listed here.

Abstract

Pancreatic cancer is highly chemoresistant. A major contributing factor is the characteristic extensive stromal or fibrotic reaction, which comprises up to 90% of the tumor volume. Over the last decade there has been intensive research into the role of the pro-fibrogenic pancreatic stellate cells (PSCs) and their interaction with pancreatic cancer cells. As a result of the significant alterations in the tumor microenvironment following activation of PSCs, tumor progression, and chemoresistance is enhanced. This review will discuss how PSCs contribute to chemoresistance in pancreatic cancer.

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