Sentinel Lymph Node in Oesophageal Cancer-a Systematic Review and Meta-analysis

Overview

Journal J Gastrointest Oncol

Date 2014 Apr 29

PMID 24772341

Citations 9

Authors

Vinayak Nagaraja

Guy D Eslick

Michael R Cox

Affiliations

Soon will be listed here.

Abstract

Background: Sentinel lymph nodes (SLNs) have been used to predict regional lymph node metastasis in patients with melanoma and breast cancer. However, the validity of the SLN hypothesis is still controversial for oesophageal cancer. We performed this meta-analysis to evaluate the feasibility and accuracy of radio-guided SLN mapping for oesophageal cancer.

Methods: A systematic search was conducted using MEDLINE, PubMed, EMBASE, Current Contents Connect, Cochrane library, Google scholar, Science Direct, and Web of Science. Original data was abstracted from each study and used to calculate a pooled event rates and 95% confidence interval (95% CI).

Results: The search identified 23 relevant articles. The overall detection rate was 0.93 (95% CI: 0.894-0.950), sensitivity 0.87 (95% CI: 0.811-0.908), negative predictive value 0.77 (95% CI: 0.568-0.890) and the accuracy was 0.88 (95% CI: 0.817-0.921). In the adenocarcinoma cohort, detection rate was 0.98 (95% CI: 0.923-0.992), sensitivity 0.84 (95% CI: 0.743-0.911) and the accuracy was 0.87(95% CI: 0.796-0.913). In the squamous cell carcinoma group, detection rate was 0.89 (95% CI: 00.792-0.943), sensitivity 0.91 (95% CI: 0.754-0.972) and the accuracy was 0.84 (95% CI: 0.732-0.914).

Conclusions: It is possible to identify and obtain a SLN before neoadjuvant therapy in oesophageal cancer. However, further work is needed to optimize radiocolloid type, refine the technique and develop a quick and accurate way to determine SLN status intraoperatively. This technique has to be further evaluated before it can be applied widely.

Citing Articles

[Evidence for the extent and oncological benefit of lymphadenectomy for esophageal cancer].

Krauss D, Schmidt T, Bruns C, Fuchs H Chirurgie (Heidelb). 2025; .

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Semaphorin 3F (SEMA3F) influences patient survival in esophageal adenocarcinoma.

Knipper K, Lyu S, Jung J, Alich N, Popp F, Schroder W Sci Rep. 2024; 14(1):20589.

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Extensive lymphadenectomy may improve survival in node negative oesophageal cancer.

Khoma O, Paredes S, Park J, Kennedy C, Falk G Sci Rep. 2024; 14(1):2711.

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The different routes of lymph node metastases in esophageal cancer and its significance.

Hutchings H, Okereke I J Thorac Dis. 2023; 15(11):5873-5876.

PMID: 38090311 PMC: 10713315. DOI: 10.21037/jtd-23-1373.

Feasibility of sentinel node navigated surgery in high-risk T1b esophageal adenocarcinoma patients using a hybrid tracer of technetium-99 m and indocyanine green.

Overwater A, Weusten B, Ruurda J, van Hillegersberg R, Bennink R, de Keizer B Surg Endosc. 2021; 36(4):2671-2679.

PMID: 34046715 PMC: 8921120. DOI: 10.1007/s00464-021-08551-6.

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