BRCA1 Founder Mutations Compared to Ovarian Cancer in Belarus

Overview

Journal Fam Cancer

Publisher Springer

Specialty Oncology

Date 2014 Apr 29

PMID 24770866

Citations 3

Authors

Alena Savanevich

Oleg Oszurek

Jan Lubinski

Cezary Cybulski

Tadeusz Debniak

Steven A Narod

Jacek Gronwald

Affiliations

Soon will be listed here.

Abstract

In Belarus and other Slavic countries, founder mutations in the BRCA1 gene are responsible for a significant proportion of breast cancer cases, but the data on contribution of these mutations to ovarian cancers are limited. To estimate the proportion of ovarian cancers in Belarus, which are dependent on BRCA1 Slavic founder mutations, we sought the presence of three most frequent mutations (BRCA1: 5382insC, C61G and, 4153delA) in 158 consecutive unselected cases of ovarian cancer. One of the three founder mutations was present in 25 of 158 unselected cases of ovarian cancer (15.8 %). We recommend that all cases of ovarian cancer in Belarus be offered genetic testing for these founder mutations. Furthermore, genetic testing of the Belarusian population will provide the opportunity to prevent a significant proportion of ovarian cancer.

Citing Articles

Contribution of BRCA1 5382insC mutation to triplene-gative and luminal types of breast cancer in Ukraine.

Samusieva A, Serga S, Klymenko S, Rybchenko L, Klimuk B, Zakhartseva L Breast Cancer Res Treat. 2022; 195(3):453-459.

PMID: 35930098 DOI: 10.1007/s10549-022-06692-3.

BRCA1 and BRCA2 mutations in ovarian cancer patients from Belarus: update.

Savanevich A, Ashuryk O, Cybulski C, Lubinski J, Gronwald J Hered Cancer Clin Pract. 2021; 19(1):13.

PMID: 33478551 PMC: 7818718. DOI: 10.1186/s13053-021-00169-y.

Application Areas of Traditional Molecular Genetic Methods and NGS in relation to Hereditary Urological Cancer Diagnosis.

Mikhaylenko D, Tanas A, Zaletaev D, Nemtsova M J Oncol. 2020; 2020:7363102.

PMID: 32612654 PMC: 7317306. DOI: 10.1155/2020/7363102.

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