RNA Epigenetics

Overview

Journal Transl Res

Publisher Elsevier

Specialty Pathology

Date 2014 Apr 29

PMID 24768686

Citations 66

Authors

Nian Liu

Tao Pan

Affiliations

Soon will be listed here.

Abstract

Mammalian messenger RNA (mRNA) and long noncoding RNA (lncRNA) contain tens of thousands of posttranscriptional chemical modifications. Among these, the N(6)-methyl-adenosine (m(6)A) modification is the most abundant and can be removed by specific mammalian enzymes. m(6)A modification is recognized by families of RNA binding proteins that affect many aspects of mRNA function. mRNA/lncRNA modification represents another layer of epigenetic regulation of gene expression, analogous to DNA methylation and histone modification.

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