The Transcription Factor Gata6 Links Tissue Macrophage Phenotype and Proliferative Renewal

Overview

Journal Science

Specialty Science

Date 2014 Apr 26

PMID 24762537

Citations 211

Authors

Marcela Rosas

Luke C Davies

Peter J Giles

Chia-Te Liao

Bashar Kharfan

Timothy C Stone

Valerie B ODonnell

Donald J Fraser

Simon A Jones

Philip R Taylor

Affiliations

Soon will be listed here.

Abstract

Tissue-resident macrophages are heterogeneous as a consequence of anatomical niche-specific functions. Many populations self-renew independently of bone marrow in the adult, but the molecular mechanisms of this are poorly understood. We determined a transcriptional profile for the major self-renewing population of peritoneal macrophages in mice. These cells specifically expressed the transcription factor Gata6. Selective deficiency of Gata6 in myeloid cells caused substantial alterations in the transcriptome of peritoneal macrophages. Gata6 deficiency also resulted in dysregulated peritoneal macrophage proliferative renewal during homeostasis and in response to inflammation, which was associated with delays in the resolution of inflammation. Our investigations reveal that the tissue macrophage phenotype is under discrete tissue-selective transcriptional control and that this is fundamentally linked to the regulation of their proliferation renewal.

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