Nucleolar Organizer Regions in Myogenic Stromal Tumours of the Stomach

Overview

Journal Virchows Arch A Pathol Anat Histopathol

Specialty Anatomy & Histology

Date 1989 Jan 1

PMID 2475965

Citations 3

Authors

H P Sinn

T Lehnert

C Kandetzki

R Waldherr

Affiliations

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Abstract

Silver staining of nucleolar organizer regions (AgNOR) was studied in 26 primary benign and malignant gastric stromal tumours of myogenic origin. The absolute number of AgNOR per nucleus and the size of AgNOR were compared with histomorphologic features of the tumours. The total number of AgNOR per nucleus in epithelioid and spindle cell leiomyosarcomas significantly (p less than 0.001) exceeded that in leiomyomas, cellular leiomyomas and epithelioid leiomyoblastomas. The mean number or the size of AgNOR did not correlate with the number of mitoses or the tumour size. In addition, large and bizarre AgNOR were seen predominantly in histologically malignant tumours. Only one exceptional epithelioid leiomyoblastoma recurred despite a lack of conventional characteristics of malignancy and a low AgNOR count. Therefore, quantitative determination of the number of AgNOR is a new independent variable in myogenic gastric tumours. It provides additional information for the histopathological evaluation of this heterogenous group of mesenchymal tumours.

Citing Articles

Diagnostic value of proliferating cell nuclear antigen for myogenic tumors of the stomach.

Oyama T, Watanabe H, IWAFUCHI M, Maejima T, Ajioka Y Gastroenterol Jpn. 1993; 28(2):193-200.

PMID: 8097999 DOI: 10.1007/BF02779220.

Nucleolar organiser regions in hyperplastic and neoplastic prostatic tissue.

Hansen A, Ostergard B Virchows Arch A Pathol Anat Histopathol. 1990; 417(1):9-13.

PMID: 1694333 DOI: 10.1007/BF01600103.

AgNOR counts and determination of malignancy in stromal tumours of the stomach and small intestine.

Beer T, Rowlands D, Crocker J J Clin Pathol. 1992; 45(2):172-4.

PMID: 1541702 PMC: 495672. DOI: 10.1136/jcp.45.2.172.

References

Appelman H, HELWIG E . Cellular leiomyomas of the stomach in 49 patients. Arch Pathol Lab Med. 1977; 101(7):373-7. View

Pike A, Lloyd R, Appelman H . Cell markers in gastrointestinal stromal tumors. Hum Pathol. 1988; 19(7):830-4. DOI: 10.1016/s0046-8177(88)80267-3. View

STOUT A . Bizarre smooth muscle tumors of the stomach. Cancer. 1962; 15:400-9. DOI: 10.1002/1097-0142(196203/04)15:2<400::aid-cncr2820150224>3.0.co;2-p. View

Egan M, Raafat F, Crocker J, Smith K . Nucleolar organizer regions in small cell tumours of childhood. J Pathol. 1987; 153(3):275-80. DOI: 10.1002/path.1711530312. View

Ranchod M, Kempson R . Smooth muscle tumors of the gastrointestinal tract and retroperitoneum: a pathologic analysis of 100 cases. Cancer. 1977; 39(1):255-62. DOI: 10.1002/1097-0142(197701)39:1<255::aid-cncr2820390139>3.0.co;2-h. View

Appleman H, HELWIG E . Gastric epithelioid leiomyoma and leiomyosarcoma (leiomyoblastoma). Cancer. 1976; 38(2):708-28. DOI: 10.1002/1097-0142(197608)38:2<708::aid-cncr2820380215>3.0.co;2-6. View

Crocker J, Nar P . Nucleolar organizer regions in lymphomas. J Pathol. 1987; 151(2):111-8. DOI: 10.1002/path.1711510203. View

Sinn H, Kandetzki C, Lehnert T, Waldherr R . [Immunohistochemical classification of stromal tumors of the stomach]. Pathologe. 1989; 10(4):244-51. View

ABRAMSON D . Leiomyoblastomas of the stomach. Surg Gynecol Obstet. 1973; 136(1):118-25. View

10.

Hall P, Crocker J, Watts A, Stansfeld A . A comparison of nucleolar organizer region staining and Ki-67 immunostaining in non-Hodgkin's lymphoma. Histopathology. 1988; 12(4):373-81. DOI: 10.1111/j.1365-2559.1988.tb01952.x. View

11.

Smith R, Crocker J . Evaluation of nucleolar organizer region-associated proteins in breast malignancy. Histopathology. 1988; 12(2):113-25. DOI: 10.1111/j.1365-2559.1988.tb01923.x. View

12.

Likovsky Z, Fabian E, Smetana K . Interphasic nucleolus organizer regions visualized by silver reaction in human hepatocytes. Hepatogastroenterology. 1987; 34(3):106-7. View

13.

Egan M, Crocker J . Nucleolar organizer regions in cutaneous tumours. J Pathol. 1988; 154(3):247-53. DOI: 10.1002/path.1711540307. View

14.

Hjermstad B, Sobin L, HELWIG E . Stromal tumors of the gastrointestinal tract: myogenic or neurogenic?. Am J Surg Pathol. 1987; 11(5):383-6. DOI: 10.1097/00000478-198705000-00007. View

15.

Shiu M, Farr G, Papachristou D, HAJDU S . Myosarcomas of the stomach: natural history, prognostic factors and management. Cancer. 1982; 49(1):177-87. DOI: 10.1002/1097-0142(19820101)49:1<177::aid-cncr2820490136>3.0.co;2-k. View

16.

Derenzini M, Romagnoli T, Mingazzini P, MARINOZZI V . Interphasic nucleolar organizer region distribution as a diagnostic parameter to differentiate benign from malignant epithelial tumors of human intestine. Virchows Arch B Cell Pathol Incl Mol Pathol. 1988; 54(6):334-40. DOI: 10.1007/BF02899231. View

17.

Crocker J, Skilbeck N . Nucleolar organiser region associated proteins in cutaneous melanotic lesions: a quantitative study. J Clin Pathol. 1987; 40(8):885-9. PMC: 1141130. DOI: 10.1136/jcp.40.8.885. View