Nucleolar Organiser Regions in Hyperplastic and Neoplastic Prostatic Tissue

Overview

Journal Virchows Arch A Pathol Anat Histopathol

Specialty Anatomy & Histology

Date 1990 Jan 1

PMID 1694333

Citations 10

Authors

A B Hansen

B Ostergard

Affiliations

Soon will be listed here.

Abstract

Silver-stained nucleolar organiser regions (AgNORs) were studied in 10 hyperplastic, 5 intra-epithelial neoplastic and 30 malignant prostatic lesions. Total AgNOR counts and types were compared with histological features. The total AgNOR count per nucleus was significantly higher (P less than 0.05) in prostatic intra-epithelial neoplasia (PIN) and adenocarcinoma compared with prostatic hyperplasia. In addition, satellite AgNORs predominated in hyperplasia, while medium-sized and large nucleoli with granular AgNORs were only observed in PIN and adenocarcinoma. The results indicate that, despite statistically significant differences, AgNOR counts are of no use for diagnosis of any single case in the groups studied, because of considerable overlap. AgNOR typing, however, may contribute to the differential diagnosis between benign and malignant lesions. We propose a new AgNOR typing system.

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Thymic epithelial tumours: evaluation of malignant grade by quantification of proliferating cell nuclear antigen and nucleolar organizer regions.

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