Toward Integrated Molecular Diagnostic System (i MDx): Principles and Applications

Overview

Journal IEEE Trans Biomed Eng

Specialties Biomedical Engineering
Biophysics

Date 2014 Apr 25

PMID 24759281

Citations 14

Authors

Seung-Min Park

Andrew F Sabour

Jun Ho Son

Sang Hun Lee

Luke P Lee

Affiliations

Soon will be listed here.

Abstract

Integrated molecular diagnostic systems ( iMDx), which are automated, sensitive, specific, user-friendly, robust, rapid, easy-to-use, and portable, can revolutionize future medicine. This review will first focus on the components of sample extraction, preservation, and filtration necessary for all point-of-care devices to include for practical use. Subsequently, we will look for low-powered and precise methods for both sample amplification and signal transduction, going in-depth to the details behind their principles. The final field of total device integration and its application to the clinical field will also be addressed to discuss the practicality for future patient care. We envision that microfluidic systems hold the potential to breakthrough the number of problems brought into the field of medical diagnosis today.

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