Adipokines, Metabolic Syndrome and Rheumatic Diseases

Overview

Journal J Immunol Res

Publisher Wiley

Specialty Allergy & Immunology

Date 2014 Apr 18

PMID 24741591

Citations 64

Authors

Vanessa Abella

Morena Scotece

Javier Conde

Veronica Lopez

Veronica Lazzaro

Jesus Pino

Juan J Gomez-Reino

Oreste Gualillo

Affiliations

Soon will be listed here.

Abstract

The metabolic syndrome (MetS) is a cluster of cardiometabolic disorders that result from the increasing prevalence of obesity. The major components of MetS include insulin resistance, central obesity, dyslipidemia, and hypertension. MetS identifies the central obesity with increased risk for cardiovascular diseases (CVDs) and type-2 diabetes mellitus (T2DM). Patients with rheumatic diseases, such as rheumatoid arthritis, osteoarthritis, systemic lupus erythematosus, and ankylosing spondylitis, have increased prevalence of CVDs. Moreover, CVD risk is increased when obesity is present in these patients. However, traditional cardiovascular risk factors do not completely explain the enhanced cardiovascular risk in this population. Thus, MetS and the altered secretion patterns of proinflammatory adipokines present in obesity could be the link between CVDs and rheumatic diseases. Furthermore, adipokines have been linked to the pathogenesis of MetS and its comorbidities through their effects on vascular function and inflammation. In the present paper, we review recent evidence of the role played by adipokines in the modulation of MetS in the general population, and in patients with rheumatic diseases.

Citing Articles

Rheumatic diseases and metabolism: where centre and periphery meet.

Lopez M, Gualillo O Nat Rev Rheumatol. 2024; 20(12):783-794.

PMID: 39478099 DOI: 10.1038/s41584-024-01178-6.

A Systematic Review of Metabolic Syndrome: Key Correlated Pathologies and Non-Invasive Diagnostic Approaches.

Giangregorio F, Mosconi E, Debellis M, Provini S, Esposito C, Garolfi M J Clin Med. 2024; 13(19).

PMID: 39407941 PMC: 11478146. DOI: 10.3390/jcm13195880.

Molecular and pathophysiological relationship between obesity and chronic inflammation in the manifestation of metabolic dysfunctions and their inflammation‑mediating treatment options (Review).

Varra F, Varras M, Varra V, Theodosis-Nobelos P Mol Med Rep. 2024; 29(6).

PMID: 38606791 PMC: 11025031. DOI: 10.3892/mmr.2024.13219.

Leptin and interleukin-1β levels associated with osteoarthritis in Vietnamese patients: a cross-sectional analysis.

Mai N, Hang N, Hanh D, Le H, Hinh N, Ky N Braz J Med Biol Res. 2023; 56:e12746.

PMID: 37703108 PMC: 10496761. DOI: 10.1590/1414-431X2023e12746.

Association of adipokines with severity of knee osteoarthritis assessed clinically and on magnetic resonance imaging.

Chong T, Tan J, Ma C, Wong S, Leung Y Osteoarthr Cartil Open. 2023; 5(4):100405.

PMID: 37664871 PMC: 10469549. DOI: 10.1016/j.ocarto.2023.100405.

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