Meat Consumption and Risk of Oral Cavity and Oropharynx Cancer: a Meta-analysis of Observational Studies

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 Apr 17

PMID 24736706

Citations 16

Authors

Jing Xu

Xin-Xin Yang

Yun-gang Wu

Xiao-Yu Li

Bo Bai

Affiliations

Soon will be listed here.

Abstract

Purpose: High meat consumption, especially red and processed meat consumption is associated with an increased risk of several cancers, however, evidence for oral cavity and oropharynx cancer is limited. Thus, we performed this meta-analysis to determine the association between intakes of total meat, processed meat, red meat, and white meat, and the risk of oral cavity and oropharynx cancer.

Methods: Electronic search of Pubmed, Embase, and Cochrane Library Central database was conducted to select relevant studies. Fixed-effect and random-effect models were used to estimate summary relative risks (RR) and the corresponding 95% confidence intervals (CIs). Potential sources of heterogeneity were detected by meta-regression. Subgroup analyses and sensitivity analysis were also performed.

Results: 12 case-control studies and one cohort study were included in the analyses, including 501,730 subjects and 4,104 oral cavity and oropharynx cancer cases. Pooled results indicated that high consumption of total meat, red meat, and white meat were not significantly associated with increased risk of oral cavity and oropharynx cancer (RR = 1.14, 95% CI[0.78-1.68]; RR = 1.05, 95% CI[0.66, 1.66] and RR = 0.81, 95% CI[0.54, 1.22], respectively), while the high consumption of processed meat was significantly associated with a 91% increased risk of oral cavity and oropharynx cancer (RR = 1.91, 95% CI [1.19-3.06]). Sensitivity analysis indicated that no significant variation in combined RR by excluding any of the study, confirming the stability of present results.

Conclusions: The present meta-analysis suggested that high consumption of processed meat was significantly associated with an increased risk of oral cavity and oropharynx cancer, while there was no significantly association between total meat, red meat or white meat and the risk of oral cavity and oropharynx cancer. More prospective cohort studies are warranted to confirm these associations.

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References

Rajkumar T, Sridhar H, Balaram P, Vaccarella S, Gajalakshmi V, Nandakumar A . Oral cancer in Southern India: the influence of body size, diet, infections and sexual practices. Eur J Cancer Prev. 2003; 12(2):135-43. DOI: 10.1097/00008469-200304000-00007. View

Wang C, Jiang H . Meat intake and risk of bladder cancer: a meta-analysis. Med Oncol. 2011; 29(2):848-55. DOI: 10.1007/s12032-011-9985-x. View

Begg C, Mazumdar M . Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994; 50(4):1088-101. View

Kazerouni N, Sinha R, Hsu C, Greenberg A, Rothman N . Analysis of 200 food items for benzo[a]pyrene and estimation of its intake in an epidemiologic study. Food Chem Toxicol. 2001; 39(5):423-36. DOI: 10.1016/s0278-6915(00)00158-7. View

De Stefani E, Boffetta P, Ronco A, Deneo-Pellegrini H, Correa P, Acosta G . Processed meat consumption and risk of cancer: a multisite case-control study in Uruguay. Br J Cancer. 2012; 107(9):1584-8. PMC: 3493769. DOI: 10.1038/bjc.2012.433. View

Mehanna H, Paleri V, West C, Nutting C . Head and neck cancer-part 1: epidemiology, presentation, and preservation. Clin Otolaryngol. 2011; 36(1):65-8. DOI: 10.1111/j.1749-4486.2010.02231.x. View

Toporcov T, Antunes J, Tavares M . Fat food habitual intake and risk of oral cancer. Oral Oncol. 2004; 40(9):925-31. DOI: 10.1016/j.oraloncology.2004.04.007. View

Levi F, Pasche C, Lucchini F, Bosetti C, La Vecchia C . Processed meat and the risk of selected digestive tract and laryngeal neoplasms in Switzerland. Ann Oncol. 2004; 15(2):346-9. DOI: 10.1093/annonc/mdh060. View

Phillips D . Polycyclic aromatic hydrocarbons in the diet. Mutat Res. 1999; 443(1-2):139-47. DOI: 10.1016/s1383-5742(99)00016-2. View

10.

Huang X . Iron overload and its association with cancer risk in humans: evidence for iron as a carcinogenic metal. Mutat Res. 2003; 533(1-2):153-71. DOI: 10.1016/j.mrfmmm.2003.08.023. View

11.

Uzcudun A, Rabanal Retolaza I, Grande A, Olivar L, Garcia A, Baron M . Pharyngeal cancer prevention: evidence from a case--control study involving 232 consecutive patients. J Laryngol Otol. 2002; 116(7):523-31. DOI: 10.1258/002221502760132395. View

12.

MIRVISH S . Role of N-nitroso compounds (NOC) and N-nitrosation in etiology of gastric, esophageal, nasopharyngeal and bladder cancer and contribution to cancer of known exposures to NOC. Cancer Lett. 1995; 93(1):17-48. DOI: 10.1016/0304-3835(95)03786-V. View

13.

Sanchez M, Martinez C, Nieto A, Castellsague X, Quintana M, Bosch F . Oral and oropharyngeal cancer in Spain: influence of dietary patterns. Eur J Cancer Prev. 2003; 12(1):49-56. DOI: 10.1097/00008469-200302000-00008. View

14.

Petridou E, Zavras A, Lefatzis D, Dessypris N, Laskaris G, Dokianakis G . The role of diet and specific micronutrients in the etiology of oral carcinoma. Cancer. 2002; 94(11):2981-8. DOI: 10.1002/cncr.10560. View

15.

WOOLF B . On estimating the relation between blood group and disease. Ann Hum Genet. 1955; 19(4):251-3. DOI: 10.1111/j.1469-1809.1955.tb01348.x. View

16.

Lissowska J, Pilarska A, Pilarski P, Samolczyk-Wanyura D, Piekarczyk J, Bardin-Mikollajczak A . Smoking, alcohol, diet, dentition and sexual practices in the epidemiology of oral cancer in Poland. Eur J Cancer Prev. 2003; 12(1):25-33. DOI: 10.1097/00008469-200302000-00005. View

17.

Garrote L, Herrero R, Reyes R, Vaccarella S, Anta J, Ferbeye L . Risk factors for cancer of the oral cavity and oro-pharynx in Cuba. Br J Cancer. 2001; 85(1):46-54. PMC: 2363910. DOI: 10.1054/bjoc.2000.1825. View

18.

DerSimonian R, Laird N . Meta-analysis in clinical trials. Control Clin Trials. 1986; 7(3):177-88. DOI: 10.1016/0197-2456(86)90046-2. View

19.

Faramawi M, Johnson E, Fry M, Sall M, Zhou Y, Yi Z . Consumption of different types of meat and the risk of renal cancer: meta-analysis of case-control studies. Cancer Causes Control. 2007; 18(2):125-33. DOI: 10.1007/s10552-006-0104-9. View

20.

Salehi M, Moradi-Lakeh M, Salehi M, Nojomi M, Kolahdooz F . Meat, fish, and esophageal cancer risk: a systematic review and dose-response meta-analysis. Nutr Rev. 2013; 71(5):257-67. DOI: 10.1111/nure.12028. View