Absence of CD9 Reduces Endometrial VEGF Secretion and Impairs Uterine Repair After Parturition

Overview

Journal Sci Rep

Specialty Science

Date 2014 Apr 17

PMID 24736431

Citations 13

Authors

Natsuko Kawano

Kenji Miyado

Noriko Yoshii

Seiya Kanai

Hidekazu Saito

Mami Miyado

Noboru Inagaki

Yasushi Odawara

Toshio Hamatani

Akihiro Umezawa

Affiliations

Soon will be listed here.

Abstract

In mammals, uterine epithelium is remodeled cyclically throughout adult life for pregnancy. Despite the expression of CD9 in the uterine epithelium, its role in maternal reproduction is unclear. Here, we addressed this issue by examining uterine secretions collected from patients undergoing fertility treatment and fertilization-competent Cd9(-/-) mice expressing CD9-GFP in their eggs (Cd9(-/-)TG). CD9 in uterine secretions was observed as extracellular matrix-like feature, and its amount of the secretions associated with repeated pregnancy failures. We also found that the litter size of Cd9(-/-)TG female mice was significantly reduced after their first birth. Severely delayed re-epithelialization of the endometrium was then occurred. Concomitantly, vascular endothelial growth factor (VEGF) was remarkably reduced in the uterine secretions of Cd9(-/-)TG female mice. These results provide the first evidence that CD9-mediated VEGF secretion plays a role in re-epithelialization of the uterus.

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