Allergic Sensitization: Food- and Protein-related Factors

Overview

Journal Clin Transl Allergy

Publisher Wiley

Specialty Allergy & Immunology

Date 2014 Apr 17

PMID 24735781

Citations 12

Authors

Scott McClain

Christal Bowman

Montserrat Fernandez-Rivas

Gregory S Ladics

Ronald van Ree

Affiliations

Soon will be listed here.

Abstract

Presented here are emerging capabilities to precisely measure endogenous allergens in soybean and maize, consideration of food matrices on allergens, and proteolytic activity of allergens. Also examined are observations of global allergy surveys and the prevalence of food allergy across different locales. Allergenic potential is considered in the context of how allergens can be characterized for their biochemical features and the potential for proteins to initiate a specific immune response. Some of the limitations in performing allergen characterization studies are examined. A combination of physical traits of proteins, the molecular interaction between cells and proteins in the human body, and the uniqueness of human culture play a role in understanding and eventually predicting protein allergy potential. The impact of measuring food allergens on determining safety for novel food crops and existing allergenic foods was highlighted with the conclusion that measuring content without the context of clinically relevant thresholds adds little value to safety. These data and findings were presented at a 2012 international symposium in Prague organized by the Protein Allergenicity Technical Committee of the International Life Sciences Institute's Health and Environmental Sciences Institute.

Citing Articles

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Prevalence and clinical features of adverse food reactions in Portuguese adolescents.

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References

Katz Y, Rajuan N, Goldberg M, Eisenberg E, Heyman E, Cohen A . Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy. J Allergy Clin Immunol. 2010; 126(1):77-82.e1. DOI: 10.1016/j.jaci.2010.04.020. View

Stevenson S, Woods C, Hong B, Kong X, Thelen J, Ladics G . Environmental effects on allergen levels in commercially grown non-genetically modified soybeans: assessing variation across north america. Front Plant Sci. 2012; 3:196. PMC: 3427918. DOI: 10.3389/fpls.2012.00196. View

Asokananthan N, Graham P, Stewart D, Bakker A, Eidne K, Thompson P . House dust mite allergens induce proinflammatory cytokines from respiratory epithelial cells: the cysteine protease allergen, Der p 1, activates protease-activated receptor (PAR)-2 and inactivates PAR-1. J Immunol. 2002; 169(8):4572-8. DOI: 10.4049/jimmunol.169.8.4572. View

Schulz O, Laing P, Sewell H, Shakib F . Der p I, a major allergen of the house dust mite, proteolytically cleaves the low-affinity receptor for human IgE (CD23). Eur J Immunol. 1995; 25(11):3191-4. DOI: 10.1002/eji.1830251131. View

Ladics G, Fry J, Goodman R, Herouet-Guicheney C, Hoffmann-Sommergruber K, Madsen C . Allergic sensitization: screening methods. Clin Transl Allergy. 2014; 4(1):13. PMC: 3990213. DOI: 10.1186/2045-7022-4-13. View

Du Toit G, Katz Y, Sasieni P, Mesher D, Maleki S, Fisher H . Early consumption of peanuts in infancy is associated with a low prevalence of peanut allergy. J Allergy Clin Immunol. 2008; 122(5):984-91. DOI: 10.1016/j.jaci.2008.08.039. View

Zuidmeer L, Goldhahn K, Rona R, Gislason D, Madsen C, Summers C . The prevalence of plant food allergies: a systematic review. J Allergy Clin Immunol. 2008; 121(5):1210-1218.e4. DOI: 10.1016/j.jaci.2008.02.019. View

Urisu A, Ebisawa M, Mukoyama T, Morikawa A, Kondo N . Japanese guideline for food allergy. Allergol Int. 2011; 60(2):221-36. DOI: 10.2332/allergolint.11-rai-0329. View

Goodman R, Vieths S, Sampson H, Hill D, Ebisawa M, Taylor S . Allergenicity assessment of genetically modified crops--what makes sense?. Nat Biotechnol. 2008; 26(1):73-81. DOI: 10.1038/nbt1343. View

10.

van Ree R, Hummelshoj L, Plantinga M, Poulsen L, Swindle E . Allergic sensitization: host-immune factors. Clin Transl Allergy. 2014; 4(1):12. PMC: 3989850. DOI: 10.1186/2045-7022-4-12. View

11.

Ricroch A, Berge J, Kuntz M . Evaluation of genetically engineered crops using transcriptomic, proteomic, and metabolomic profiling techniques. Plant Physiol. 2011; 155(4):1752-61. PMC: 3091128. DOI: 10.1104/pp.111.173609. View

12.

Wan H, Winton H, Soeller C, Tovey E, Gruenert D, Thompson P . Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions. J Clin Invest. 1999; 104(1):123-33. PMC: 408401. DOI: 10.1172/JCI5844. View

13.

Madsen C, Hattersley S, Buck J, Gendel S, Houben G, Hourihane J . Approaches to risk assessment in food allergy: report from a workshop ''developing a framework for assessing the risk from allergenic foods". Food Chem Toxicol. 2008; 47(2):480-9. DOI: 10.1016/j.fct.2008.12.001. View

14.

Maneechotesuwan K, Wamanuttajinda V, Kasetsinsombat K, Huabprasert S, Yaikwawong M, Barnes P . Der p 1 suppresses indoleamine 2, 3-dioxygenase in dendritic cells from house dust mite-sensitive patients with asthma. J Allergy Clin Immunol. 2008; 123(1):239-48. DOI: 10.1016/j.jaci.2008.10.018. View

15.

Wan H, Winton H, Soeller C, Gruenert D, Thompson P, Cannell M . Quantitative structural and biochemical analyses of tight junction dynamics following exposure of epithelial cells to house dust mite allergen Der p 1. Clin Exp Allergy. 2000; 30(5):685-98. DOI: 10.1046/j.1365-2222.2000.00820.x. View

16.

Ghaemmaghami A, Gough L, Sewell H, Shakib F . The proteolytic activity of the major dust mite allergen Der p 1 conditions dendritic cells to produce less interleukin-12: allergen-induced Th2 bias determined at the dendritic cell level. Clin Exp Allergy. 2002; 32(10):1468-75. DOI: 10.1046/j.1365-2745.2002.01504.x. View

17.

Poulsen L, Ladics G, McClain S, Doerrer N, van Ree R . Sensitizing properties of proteins: executive summary. Clin Transl Allergy. 2014; 4(1):10. PMC: 3989794. DOI: 10.1186/2045-7022-4-10. View

18.

Houston N, Lee D, Stevenson S, Ladics G, Bannon G, McClain S . Quantitation of soybean allergens using tandem mass spectrometry. J Proteome Res. 2010; 10(2):763-73. DOI: 10.1021/pr100913w. View

19.

Grimshaw K, King R, Nordlee J, Hefle S, Warner J, Hourihane J . Presentation of allergen in different food preparations affects the nature of the allergic reaction--a case series. Clin Exp Allergy. 2003; 33(11):1581-5. DOI: 10.1046/j.1365-2222.2003.01795.x. View

20.

Kato Y, Oozawa E, Matsuda T . Decrease in antigenic and allergenic potentials of ovomucoid by heating in the presence of wheat flour: dependence on wheat variety and intermolecular disulfide bridges. J Agric Food Chem. 2001; 49(8):3661-5. DOI: 10.1021/jf0102766. View