» Articles » PMID: 24733970

Emerging Role of MicroRNAs in Major Depressive Disorder: Diagnosis and Therapeutic Implications

Overview
Specialty Neurology
Date 2014 Apr 16
PMID 24733970
Citations 76
Authors
Affiliations
Soon will be listed here.
Abstract

Major depressive disorder (MDD) is a major public health concern. Despite tremendous advances, the pathogenic mechanisms associated with MDD are still unclear. Moreover, a significant number of MDD subjects do not respond to the currently available medication. MicroRNAs (miRNAs) are a class of small noncoding RNAs that control gene expression by modulating translation, messenger RNA (mRNA) degradation, or stability of mRNA targets. The role of miRNAs in disease pathophysiology is emerging rapidly. Recent studies demonstrating the involvement of miRNAs in several aspects of neural plasticity, neurogenesis, and stress response, and more direct studies in human postmortem brain provide strong evidence that miRNAs can not only play a critical role in MDD pathogenesis, but can also open up new avenues for the development of therapeutic targets. Circulating miRNAs are now being considered as possible biomarkers in disease pathogenesis and in monitoring therapeutic responses because of the presence and/or release of miRNAs in blood cells as well as in other peripheral tissues. In this review, these aspects are discussed in a comprehensive and critical manner.

Citing Articles

MicroRNA signatures in neuroplasticity, neuroinflammation and neurotransmission in association with depression.

Choudhary A, Kumar A, Jindal M, Rhuthuparna M, Munshi A J Physiol Biochem. 2024; .

PMID: 39695016 DOI: 10.1007/s13105-024-01065-4.


Relationship Between the Occurrence of Depression and (rs6877842, rs10719) and (rs11077) Single-Nucleotide Polymorphisms in the Polish Population: A Case-Control Study.

Kowalczyk M, Kowalczyk E, Talarowska M, Majsterek I, Skrzypek M, Poplawski T Int J Mol Sci. 2024; 25(22).

PMID: 39596271 PMC: 11594337. DOI: 10.3390/ijms252212204.


Exploring miRNA Biomarkers in Major Depressive Disorder: A Molecular Medicine Perspective.

Prodan-Barbulescu C, Ghenciu L, Seclaman E, Bujor G, Enatescu V, Danila A Curr Issues Mol Biol. 2024; 46(10):10846-10853.

PMID: 39451524 PMC: 11506240. DOI: 10.3390/cimb46100644.


Deciphering the role of miRNA-134 in the pathophysiology of depression: A comprehensive review.

Wang Y, Huang Y, Luo X, Lai X, Yu L, Zhao Z Heliyon. 2024; 10(19):e39026.

PMID: 39435111 PMC: 11492588. DOI: 10.1016/j.heliyon.2024.e39026.


Integrated Long Noncoding RNA and Messenger RNA Expression Analysis Identifies Molecules Specifically Associated With Resiliency and Susceptibility to Depression and Antidepressant Response.

Wang Q, Wang H, Dwivedi Y Biol Psychiatry Glob Open Sci. 2024; 4(6):100365.

PMID: 39257693 PMC: 11385423. DOI: 10.1016/j.bpsgos.2024.100365.


References
1.
Hanson E, Lubenow H, Ballantyne J . Identification of forensically relevant body fluids using a panel of differentially expressed microRNAs. Anal Biochem. 2009; 387(2):303-14. DOI: 10.1016/j.ab.2009.01.037. View

2.
Uchida S, Nishida A, Hara K, Kamemoto T, Suetsugi M, Fujimoto M . Characterization of the vulnerability to repeated stress in Fischer 344 rats: possible involvement of microRNA-mediated down-regulation of the glucocorticoid receptor. Eur J Neurosci. 2008; 27(9):2250-61. DOI: 10.1111/j.1460-9568.2008.06218.x. View

3.
Bruno I, Karam R, Huang L, Bhardwaj A, Lou C, Shum E . Identification of a microRNA that activates gene expression by repressing nonsense-mediated RNA decay. Mol Cell. 2011; 42(4):500-10. PMC: 3123134. DOI: 10.1016/j.molcel.2011.04.018. View

4.
Innamorati M, Pompili M, Gonda X, Amore M, Serafini G, Niolu C . Psychometric properties of the Gotland Scale for Depression in Italian psychiatric inpatients and its utility in the prediction of suicide risk. J Affect Disord. 2011; 132(1-2):99-103. DOI: 10.1016/j.jad.2011.02.003. View

5.
Fiore R, Khudayberdiev S, Christensen M, Siegel G, Flavell S, Kim T . Mef2-mediated transcription of the miR379-410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels. EMBO J. 2009; 28(6):697-710. PMC: 2647767. DOI: 10.1038/emboj.2009.10. View