Medial Temporal Atrophy in Early and Late-onset Alzheimer's Disease

Overview

Journal Neurobiol Aging

Publisher Elsevier

Specialties Geriatrics
Neurology
Physiology

Date 2014 Apr 12

PMID 24721821

Citations 40

Authors

Enrica Cavedo

Michela Pievani

Marina Boccardi

Samantha Galluzzi

Martina Bocchetta

Matteo Bonetti

Paul M Thompson

Giovanni B Frisoni

Affiliations

Soon will be listed here.

Abstract

Late-onset and early-onset Alzheimer's disease (LOAD, EOAD) affect different neural systems and may be separate nosographic entities. The most striking differences are in the medial temporal lobe, severely affected in LOAD and relatively spared in EOAD. We assessed amygdalar morphology and volume in 18 LOAD and 18 EOAD patients and 36 aged-matched controls and explored their relationship with the hippocampal volume. Three-dimensional amygdalar shape was reconstructed with the radial atrophy mapping technique, hippocampal volume was measured using a manual method. Atrophy was greater in LOAD than EOAD: 25% versus 17% in the amygdala and 20% versus 13% in the hippocampus. In the amygdala, LOAD showed significantly greater tissue loss than EOAD in the right dorsal central, lateral, and basolateral nuclei (20%-30% loss, p < 0.03), all known to be connected to limbic regions. In LOAD but not EOAD, greater hippocampal atrophy was associated with amygdalar atrophy in the left dorsal central and medial nuclei (r = 0.6, p < 0.05) also part of the limbic system. These findings support the notion that limbic involvement is a prominent feature of LOAD but not EOAD.

Citing Articles

Individualized, cross-validated prediction of future dementia using cognitive assessments in people with mild cognitive symptoms.

Borland E, Mattson-Carlgren N, Tideman P, Stomrud E, Hansson O, Palmqvist S Alzheimers Dement. 2024; 20(12):8625-8638.

PMID: 39417379 PMC: 11667515. DOI: 10.1002/alz.14305.

Heterogeneity of factors associated with cognitive decline and cortical atrophy in early- versus late-onset Alzheimer's disease.

Cho J, Yoon C, Shin J, Seo H, Kim W, Na H Sci Rep. 2024; 14(1):20429.

PMID: 39227668 PMC: 11372067. DOI: 10.1038/s41598-024-71402-6.

Alterations of Structural Network Efficiency in Early-Onset and Late-Onset Alzheimer's Disease.

Heo S, Yoon C, Kim S, Kim W, Na D, Noh Y J Clin Neurol. 2024; 20(3):265-275.

PMID: 38330417 PMC: 11076196. DOI: 10.3988/jcn.2023.0092.

Repetitive transcranial magnetic stimulation for apathy in patients with neurodegenerative conditions, cognitive impairment, stroke, and traumatic brain injury: a systematic review.

Espiritu A, Hara T, Tolledo J, Blair M, Burhan A Front Psychiatry. 2023; 14:1259481.

PMID: 38034914 PMC: 10684725. DOI: 10.3389/fpsyt.2023.1259481.

Uncovering the System Vulnerability and Criticality of Human Brain Under Dynamical Neuropathological Events in Alzheimer's Disease.

Zhang J, Liu Q, Zhang H, Dai M, Song Q, Yang D J Alzheimers Dis. 2023; 95(3):1201-1219.

PMID: 37661878 PMC: 11177206. DOI: 10.3233/JAD-230027.

References

Krasuski J, Alexander G, Horwitz B, Daly E, Murphy D, Rapoport S . Volumes of medial temporal lobe structures in patients with Alzheimer's disease and mild cognitive impairment (and in healthy controls). Biol Psychiatry. 1998; 43(1):60-8. DOI: 10.1016/s0006-3223(97)00013-9. View

Scott S, DeKosky S, Scheff S . Volumetric atrophy of the amygdala in Alzheimer's disease: quantitative serial reconstruction. Neurology. 1991; 41(3):351-6. DOI: 10.1212/wnl.41.3.351. View

Jacobs D, Sano M, Marder K, Bell K, Bylsma F, LaFleche G . Age at onset of Alzheimer's disease: relation to pattern of cognitive dysfunction and rate of decline. Neurology. 1994; 44(7):1215-20. DOI: 10.1212/wnl.44.7.1215. View

Thompson P, MacDonald D, Mega M, Holmes C, Evans A, Toga A . Detection and mapping of abnormal brain structure with a probabilistic atlas of cortical surfaces. J Comput Assist Tomogr. 1997; 21(4):567-81. DOI: 10.1097/00004728-199707000-00008. View

Catani M, DellAcqua F, Thiebaut de Schotten M . A revised limbic system model for memory, emotion and behaviour. Neurosci Biobehav Rev. 2013; 37(8):1724-37. DOI: 10.1016/j.neubiorev.2013.07.001. View

Kono K, Kuzuya F, Yamamoto T, Endo H . Comparative study of cerebral ventricular dilation and cognitive function in patients with Alzheimer's disease of early versus late onset. J Geriatr Psychiatry Neurol. 1994; 7(1):39-45. View

Hixson J, Vernier D . Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J Lipid Res. 1990; 31(3):545-8. View

Raux G, Guyant-Marechal L, Martin C, Bou J, Penet C, Brice A . Molecular diagnosis of autosomal dominant early onset Alzheimer's disease: an update. J Med Genet. 2005; 42(10):793-5. PMC: 1735922. DOI: 10.1136/jmg.2005.033456. View

Heun R, Mazanek M, Atzor K, Tintera J, Gawehn J, Burkart M . Amygdala-hippocampal atrophy and memory performance in dementia of Alzheimer type. Dement Geriatr Cogn Disord. 1997; 8(6):329-36. DOI: 10.1159/000106651. View

10.

Tsuchiya K, Kosaka K . Neuropathological study of the amygdala in presenile Alzheimer's disease. J Neurol Sci. 1990; 100(1-2):165-73. DOI: 10.1016/0022-510x(90)90029-m. View

11.

Folstein M, Folstein S, McHugh P . "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12(3):189-98. DOI: 10.1016/0022-3956(75)90026-6. View

12.

van der Vlies A, Staekenborg S, Admiraal-Behloul F, Prins N, Barkhof F, Vrenken H . Associations between magnetic resonance imaging measures and neuropsychological impairment in early and late onset alzheimer's disease. J Alzheimers Dis. 2013; 35(1):169-78. DOI: 10.3233/JAD-121291. View

13.

Galluzzi S, Testa C, Boccardi M, Bresciani L, Benussi L, Ghidoni R . The Italian Brain Normative Archive of structural MR scans: norms for medial temporal atrophy and white matter lesions. Aging Clin Exp Res. 2009; 21(4-5):266-76. DOI: 10.1007/BF03324915. View

14.

Qiu A, Fennema-Notestine C, Dale A, Miller M . Regional shape abnormalities in mild cognitive impairment and Alzheimer's disease. Neuroimage. 2009; 45(3):656-61. PMC: 2847795. DOI: 10.1016/j.neuroimage.2009.01.013. View

15.

Meyer M, Tschanz J, Norton M, Welsh-Bohmer K, Steffens D, Wyse B . APOE genotype predicts when--not whether--one is predisposed to develop Alzheimer disease. Nat Genet. 1998; 19(4):321-2. DOI: 10.1038/1206. View

16.

Selden N, Gitelman D, Parrish T, Mesulam M . Trajectories of cholinergic pathways within the cerebral hemispheres of the human brain. Brain. 1999; 121 ( Pt 12):2249-57. DOI: 10.1093/brain/121.12.2249. View

17.

Gomez-Isla T, Growdon W, McNamara M, Nochlin D, Bird T, Arango J . The impact of different presenilin 1 andpresenilin 2 mutations on amyloid deposition, neurofibrillary changes and neuronal loss in the familial Alzheimer's disease brain: evidence for other phenotype-modifying factors. Brain. 1999; 122 ( Pt 9):1709-19. DOI: 10.1093/brain/122.9.1709. View

18.

Pruessner J, Li L, Serles W, Pruessner M, Collins D, Kabani N . Volumetry of hippocampus and amygdala with high-resolution MRI and three-dimensional analysis software: minimizing the discrepancies between laboratories. Cereb Cortex. 2000; 10(4):433-42. DOI: 10.1093/cercor/10.4.433. View

19.

Moller C, Vrenken H, Jiskoot L, Versteeg A, Barkhof F, Scheltens P . Different patterns of gray matter atrophy in early- and late-onset Alzheimer's disease. Neurobiol Aging. 2013; 34(8):2014-22. DOI: 10.1016/j.neurobiolaging.2013.02.013. View

20.

Price J . Comparative aspects of amygdala connectivity. Ann N Y Acad Sci. 2003; 985:50-8. DOI: 10.1111/j.1749-6632.2003.tb07070.x. View