Insulin B Chain Functions As an Effective Competitor of Antigen Presentation Via Peptide Homologies Present in the Thymus

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1989 Jun 1

PMID 2471779

Citations 2

Authors

G G Miller

J F Hoy

J W Thomas

Affiliations

Soon will be listed here.

Abstract

The B chain of mammalian insulins contains appropriately spaced amino acids that predict recognition by T cells. However, all T cell clones from an HLA-DR1, Dw6 diabetic donor recognize epitopes associated with the A chain, and the B chain was found to inhibit these responses. Effective intramolecular competition at the level of the APC, not a direct effect on the T cell, is responsible for the inhibition. Insulin B chain contains two clusters of amino acid homology with the TCR beta chain and B chain peptides lacking these clusters do not compete for antigen presentation. A hole in the repertoire for T cells that recognize this portion of the insulin molecule may arise in the thymus by deletion of T cells that recognize similar peptides.

Citing Articles

Naturally processed heterodimeric disulfide-linked insulin peptides bind to major histocompatibility class II molecules on thymic epithelial cells.

Forquet F, Hadzija M, Semple J, Speck E, Delovitch T Proc Natl Acad Sci U S A. 1994; 91(9):3936-40.

PMID: 8171015 PMC: 43697. DOI: 10.1073/pnas.91.9.3936.

Identification of an autologous insulin B chain peptide as a target antigen for H-2Kb-restricted cytotoxic T lymphocytes.

Sheil J, Shepherd S, Klimo G, Paterson Y J Exp Med. 1992; 175(2):545-52.

PMID: 1370687 PMC: 2119120. DOI: 10.1084/jem.175.2.545.

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