Phenolic Polyketides from the Co-cultivation of Marine-derived Penicillium Sp. WC-29-5 and Streptomyces Fradiae 007

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2014 Apr 10

PMID 24714124

Citations 19

Authors

Yi Wang

Liping Wang

Yibin Zhuang

Fandong Kong

Cuixian Zhang

Weiming Zhu

Affiliations

Soon will be listed here.

Abstract

Penicillium sp. WC-29-5 was co-cultured with Streptomyces fradiae 007 to produce five natural products (1-3, 4a and 4b) that were isolated and characterized by spectroscopic analysis. Interestingly, these compounds were found to be different from those produced in discrete fungal and bacterial controls. Among these compounds, the absolute configurations of compounds 4a and 4b were determined for the first time by X-ray single crystal diffraction experiments and electronic circular dichroism (ECD) calculations. An evaluation of the cytotoxic activities of these compounds revealed that 4b was moderately cytotoxic towards HL-60 and H1975 tumor cells with IC₅₀ values of 3.73 and 5.73 µM, respectively, whereas compound 4a was only moderately cytotoxic towards H1975 cells with an IC₅₀ value of 3.97 µM.

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