Molecular Imaging in Stem Cell Therapy for Spinal Cord Injury

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2014 Apr 5

PMID 24701583

Citations 9

Authors

Fahuan Song

Mei Tian

Hong Zhang

Affiliations

Soon will be listed here.

Abstract

Spinal cord injury (SCI) is a serious disease of the center nervous system (CNS). It is a devastating injury with sudden loss of motor, sensory, and autonomic function distal to the level of trauma and produces great personal and societal costs. Currently, there are no remarkable effective therapies for the treatment of SCI. Compared to traditional treatment methods, stem cell transplantation therapy holds potential for repair and functional plasticity after SCI. However, the mechanism of stem cell therapy for SCI remains largely unknown and obscure partly due to the lack of efficient stem cell trafficking methods. Molecular imaging technology including positron emission tomography (PET), magnetic resonance imaging (MRI), optical imaging (i.e., bioluminescence imaging (BLI)) gives the hope to complete the knowledge concerning basic stem cell biology survival, migration, differentiation, and integration in real time when transplanted into damaged spinal cord. In this paper, we mainly review the molecular imaging technology in stem cell therapy for SCI.

Citing Articles

The Current Update of Conventional and Innovative Treatment Strategies for Central Nervous System Injury.

Tsai M, Wu C, Wu C, Chen C Biomedicines. 2024; 12(8).

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Longitudinal Magnetic Resonance Imaging Tracking of Transplanted Neural Progenitor Cells in the Spinal Cord Utilizing the Bright-Ferritin Mechanism.

Luo Z, Zhuang K, Kim S, Vollett K, Lou Z, Wang J Stem Cells Transl Med. 2024; 13(6):546-558.

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Evaluation of Traumatic Spinal Cord Injury in a Rat Model Using Tc-GA-5 as a Potential In Vivo Tracer.

Izquierdo-Sanchez V, C Zambrano-Rodriguez P, Pena-Merino N, Bolanos-Puchet S, Reyes-Alva H, Martinez-Cruz A Molecules. 2021; 26(23).

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Does vitamin C have the ability to augment the therapeutic effect of bone marrow-derived mesenchymal stem cells on spinal cord injury?.

Salem N, Salem M, Elmaghrabi M, Elawady M, Elawady M, Sabry D Neural Regen Res. 2018; 12(12):2050-2058.

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Stem Cells and Labeling for Spinal Cord Injury.

Gazdic M, Volarevic V, Arsenijevic A, Erceg S, Moreno-Manzano V, Arsenijevic N Int J Mol Sci. 2016; 18(1).

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