XPA Gene Rs1800975 Single Nucleotide Polymorphism and Lung Cancer Risk: a Meta-analysis

Overview

Journal Tumour Biol

Publisher Sage Publications

Specialty Oncology

Date 2014 Apr 4

PMID 24696258

Citations 10

Authors

Yuqing Lou

Rong Li

Yanwei Zhang

Runbo Zhong

Jun Pei

Liwen Xiong

Xueyan Zhang

Baohui Han

Affiliations

Soon will be listed here.

Abstract

No clear consensus has been reached on the XPA gene rs1800975 polymorphism and lung cancer risk. We performed a meta-analysis in an effort to systematically explore the possible association. We conducted a computer retrieval of PubMed, Embase, Wanfang, China National Knowledge Infrastructure Platform, and VIP databases prior to November 2013. References of retrieved articles were also screened. The fixed- and the random-effects model were applied for dichotomous outcomes to combine the results of the individual studies. According to the inclusion criteria, 10 articles (11 studies) were finally included. In overall, statistical association could be found between rs1800975 polymorphism and lung cancer in recessive genetic model [AA vs. (AG + GG): P = 0.02, OR = 1.16, 95% CI 1.02-1.31, P heterogeneity = 0.14, fixed-effects model]. In the East Asians, significant association was found in allele comparison model (A vs. G: P = 0.03, OR = 1.13, 95% CI 1.01-1.26, P heterogeneity = 0.39, fixed-effects model), in recessive genetic model [AA vs. (AG + GG): P = 0.005, OR = 1.30, 95% CI 1.08-1.56, P heterogeneity = 0.58, fixed-effects model] and in the homozygote comparison (AA vs. GG: P = 0.02, OR = 1.30, 95% CI 1.04-1.63, P heterogeneity = 0.39, fixed-effects model). No evidence suggested that rs1800975 polymorphism might associate with lung cancer in other ethnicities. Stratification analysis performed by histologic types indicated that AA genotype might represent a risk factor for squamous cell carcinoma [AA vs. (AG + GG): P = 0.01, OR = 1.42, 95% CI 1.08-1.86, P heterogeneity = 0.27, fixed-effects model; AA vs. GG: P = 0.03, OR = 1.43, 95% CI 1.04-1.96, P heterogeneity = 0.21, fixed-effects model]. No association was observed in adenocarcinoma subgroup. Our study suggested that XPA rs1800975 polymorphism might associate with lung cancer risk in overall and in East Asians. This polymorphism might also associate with squamous cell carcinoma.

Citing Articles

Association of human rs1800975 polymorphism and cancer susceptibility: an integrative analysis of 71 case-control studies.

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Association of XPA polymorphism with breast cancer risk: A meta-analysis.

Zhang Y, Guo Q, Yin X, Zhu X, Zhao L, Zhang Z Medicine (Baltimore). 2018; 97(26):e11276.

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Modulation of Colorectal Cancer Risk by Polymorphisms in 51Gln/His, 64Ile/Val, and 148Asp/Glu of APEX Gene; 23Gly/Ala of XPA Gene; and 689Ser/Arg of ERCC4 Gene.

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Nucleotide excision repair pathway gene polymorphisms are linked to breast cancer risk in a Chinese population.

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