The Impact of Stimulus Valence and Emotion Regulation on Sustained Brain Activation: Task-rest Switching in Emotion

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 Apr 1

PMID 24682003

Citations 8

Authors

Jan-Peter Lamke

Judith K Daniels

Denise Dorfel

Michael Gaebler

Rasha Abdel Rahman

Falk Hummel

Susanne Erk

Henrik Walter

Affiliations

Soon will be listed here.

Abstract

Task-rest interactions, defined as the modulation of brain activation during fixation periods depending on the preceding stimulation and experimental manipulation, have been described repeatedly for different cognitively demanding tasks in various regions across the brain. However, task-rest interactions in emotive paradigms have received considerably less attention. In this study, we therefore investigated task-rest interactions evoked by the induction and instructed regulation of negative emotion. Whole-brain, functional MRI data were acquired from 55 healthy participants. Two-level general linear model statistics were computed to test for differences between conditions, separately for stimulation and for fixation periods, as well as for interactions between stimulation and fixation (task-rest interactions). Results showed that the regulation of negative emotion led to reverse task-rest interactions (decreased activation during stimulation but increased activation during fixation) in the amygdala as well as in visual cortex regions and to concordant task-rest interactions (increased activation during both, stimulation and fixation) in the dorsolateral prefrontal cortex as well as in a number of brain regions at the intersection of the default mode and the dorsal attention networks. Thus, this first whole-brain investigation of task-rest interactions following the induction and regulation of negative emotion identified a widespread specific modulation of brain activation in regions subserving emotion generation and regulation as well as regions implicated in attention and default mode.

Citing Articles

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