Multifunctional Fe5 C2 Nanoparticles: a Targeted Theranostic Platform for Magnetic Resonance Imaging and Photoacoustic Tomography-guided Photothermal Therapy

Overview

Journal Adv Mater

Date 2014 Mar 29

PMID 24677251

Citations 46

Authors

Jing Yu

Ce Yang

Jingdingsha Li

Yichen Ding

Lei Zhang

Muhammad Zubair Yousaf

Jian Lin

Rui Pang

Lanbin Wei

Lili Xu

Fugeng Sheng

Changhui Li

Gongjie Li

Lingyun Zhao

Yanglong Hou

Affiliations

Soon will be listed here.

Abstract

Fe5 C2 NPs exhibit a high contrast in magnetic resonance imaging (MRI), superior photoacoustic tomography improvements, and efficient photothermal therapy (PTT) due to their unique core/shell structure, with a magnetic core and carbon shell. By conjugating a new class of affinity proteins (ZHER2:342), they can target to tumor cells with low cytotoxicity, and kill them through laser irritation. It is also possible to ablate tumors under guidance by MRI and PTT without noticeable side effects.

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