Coacervate Whey Protein Improves Inflammatory Milieu in Mice Fed with High-fat Diet

Overview

Journal Nutr Metab (Lond)

Publisher Biomed Central

Date 2014 Mar 29

PMID 24673809

Citations 1

Authors

Mayara Franzoi Moreno

Gabriel Inacio de Morais Honorato de Souza

Ana Claudia Losinskas Hachul

Bruno Dos Santos

Marcos Hiromu Okuda

Nelson Inacio Pinto Neto

Valter Tadeu Boldarine

Elisa Esposito

Eliane Beraldi Ribeiro

Claudia Maria da Penha Oller do Nascimento

Aline de Piano Ganen

Lila Missae Oyama

Affiliations

Soon will be listed here.

Abstract

Background: Functional foods with bioactive properties may help in treat obesity, as they can lead to a decreased risks of inflammatory diseases. The aim of this study was to investigate the effects of chitosan coacervate whey protein on the proinflammatory processes in mice fed with high-fat diet.

Methods: Mice were divided into two groups receiving either a normolipidic or high-fat diet; the animals in each of the two diet groups were given a diet supplement of either coacervate (gavage, 36 mg protein/kg of body weight) or tap water for four weeks [groups: normolipidic diet plus water (C); normolipidic diet and coacervate (CC); high-fat diet and water (H); and high-fat diet and coacervate (HC)].

Results: The high-fat diet promoted inflammation, possibly by decreased adiponectin/sum of adipose tissues ratio and increased phosphorylation of NF-κB p50. In HC we observed a positive correlation between IL-10 and TNF-α in mesenteric adipose tissue, retroperitoneal adipose tissue and liver tissue. We also observed a positive correlation between lipopolisaccharide with IL-10 in the liver tissue.

Conclusions: High-fat diet treatment promoted metabolic alterations and inflammation, and chitosan coacervate whey protein modulated inflammatory milieu.

Citing Articles

Preventive effects of chitosan coacervate whey protein on body composition and immunometabolic aspect in obese mice.

de Souza G, Santamarina A, Santana A, Lira F, de Laquila R, Moreno M Mediators Inflamm. 2014; 2014:281097.

PMID: 25309049 PMC: 4182892. DOI: 10.1155/2014/281097.

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