Adipose Tissue is a Regulated Source of Interleukin-10

Overview

Journal Cytokine

Specialties Allergy & Immunology
Biology

Date 2005 Mar 8

PMID 15749027

Citations 52

Authors

Cristiana E Juge-Aubry

Emmanuel Somm

Agnes Pernin

Navid Alizadeh

Vittorio Giusti

Jean-Michel Dayer

Christoph A Meier

Affiliations

Soon will be listed here.

Abstract

White adipose tissue (WAT) is the source of pro- and anti-inflammatory cytokines and we have recently shown that this tissue is a major source of the anti-inflammatory interleukin (IL)-1 receptor antagonist (IL-1Ra). We now aimed at identifying additional adipose-derived cytokines, which might serve as regulators of IL-1Ra. We demonstrate here for the first time that the antiinflammatory cytokine IL-10 is secreted by human WAT explants and that it is up-regulated by LPS and TNF-alpha in vitro, as well as in obesity in humans (2- and 6-fold increase in subcutaneous and visceral WAT, respectively) and rodents (4-fold increase).

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