X-ray Crystallographic Structures of Trimers and Higher-order Oligomeric Assemblies of a Peptide Derived from Aβ(17-36)

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2014 Mar 28

PMID 24669800

Citations 52

Authors

Ryan K Spencer

Hao Li

James S Nowick

Affiliations

Soon will be listed here.

Abstract

A peptide derived from Aβ17-36 crystallizes to form trimers that further associate to form higher-order oligomers. The trimers consist of three highly twisted β-hairpins in a triangular arrangement. Two trimers associate face-to-face in the crystal lattice to form a hexamer; four trimers in a tetrahedral arrangement about a central cavity form a dodecamer. These structures provide a working model for the structures of oligomers associated with neurodegeneration in Alzheimer's disease.

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