MiR-99a and -99b Inhibit Cervical Cancer Cell Proliferation and Invasion by Targeting MTOR Signaling Pathway

Overview

Journal Med Oncol

Publisher Springer

Specialty Oncology

Date 2014 Mar 27

PMID 24668416

Citations 36

Authors

Li Wang

Lihua Chang

Zhaorong Li

Qing Gao

Dongge Cai

Yingfang Tian

Lingxia Zeng

Mu Li

Affiliations

Soon will be listed here.

Abstract

MicroRNAs were demonstrated to play an important role in the regulation of gene expression. Here, we showed that miR-99a and -99b (miR-99a/b) were down-regulated in human cervical cancer patient tissues and were negatively related with lymphatic metastasis. In addition, overexpression of miR-99a/b inhibited cell growth and invasion, whereas suppression of miR-99a/b yielded the reverse phenotype. Dual luciferase report assay revealed that mTOR was identified as a novel target gene of both miR-99a and -99b. Altogether, these results suggested that miR-99a/b directly and negatively regulated mTOR expression in cervical cancer cells, and enforced the importance of miR-99a/b and their targets in the malignant phenotypes of cervical carcinogenesis.

Citing Articles

Value of non-coding RNAs to assess lymph node status in cervical cancer.

Dabi Y, Favier A, Razakamanantsoa L, Suisse S, Marie Y, Touboul C Front Oncol. 2023; 13:1144672.

PMID: 37234986 PMC: 10206114. DOI: 10.3389/fonc.2023.1144672.

High miR-99b expression is associated with cell proliferation and worse patient outcomes in breast cancer.

Oshi M, Tokumaru Y, Benesch M, Sugito N, Wu R, Yan L Am J Cancer Res. 2022; 12(10):4840-4852.

PMID: 36381329 PMC: 9641402.

Down-regulated expression of is associated with lymph node metastasis and predicts poor outcome in stage IB cervical squamous cell carcinoma: a case-control study.

Zhang G, Zhang R, Bai P, Li S, Zuo J, Zhang Y Ann Transl Med. 2022; 10(12):663.

PMID: 35845501 PMC: 9279763. DOI: 10.21037/atm-22-2483.

miR-99a-5p inhibits glycolysis and induces cell apoptosis in cervical cancer by targeting RRAGD.

Wang G, Lu Y, Di S, Xie M, Jing F, Dai X Oncol Lett. 2022; 24(1):228.

PMID: 35720506 PMC: 9185141. DOI: 10.3892/ol.2022.13349.

Retracted Article: RNA-sequencing identified miR-3681 as a negative regulator in the proliferation and migration of cervical cancer cells the posttranscriptional suppression of HGFR.

Shi F, Zhang Y, Wang J, Su J, Liu Z, Wang T RSC Adv. 2022; 9(39):22376-22383.

PMID: 35519460 PMC: 9066695. DOI: 10.1039/c9ra01785b.

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